PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1928
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Article Mice Extrapolate Temporal Information Based on Previously Learned Spatiotemporal Mappings: An Asymmetrical Case(Springer, 2026-01-06) Gur, Ezgi; Duyan, Yalcin A.; Toptas, Pinar; Balci, FuatOne of the computational affordances of isomorphic magnitude representations is the extrapolation of temporal information based on previously experienced spatiotemporal pairings. We initially trained mice on the association of two intervals (10 s and 30 s) with two hoppers (H2 and H4, counterbalanced) in a five-choice nose-poke box with the following setup. One of the three novel hoppers (H1) neighbored H2 only, the other novel hopper (H5) neighbored H4 only, and the third novel hopper (H3) neighbored H2 and H4 (H1Novel -> H2Trained -> H3Novel -> H4Trained -> H5Novel). During test trials, one of the five hoppers was illuminated. We estimated the trial time at which the anticipatory response rate was maximal (peak time) separately for each hopper. Mice extrapolated temporal information only in a forward fashion; the peak time for H5 was longer than that for H4. Mice did not extrapolate temporal information backward; the timed response curves in H1 and H3 were closely similar to those in H2. Thus, our findings suggest that mice can extrapolate temporal information, but also indicate that the computations underlying this process are directionally constrained. We discuss the possible reasons behind asymmetrical extrapolation.Article Citation - WoS: 16Citation - Scopus: 16The Timing Database: an Open-Access, Live Repository for Interval Timing Studies(Springer, 2023-01-03) Brochard, Renaud; Karşılar, Hakan; Akdoğan, Başak; De Corte, Benjamin; Aydoğan, Turaç; Baccarani, Alessia; Duyan, Yalçın Akın; Balci, FuatInterval timing refers to the ability to perceive and remember intervals in the seconds to minutes range. Our contemporary understanding of interval timing is derived from relatively small-scale, isolated studies that investigate a limited range of intervals with a small sample size, usually based on a single task. Consequently, the conclusions drawn from individual studies are not readily generalizable to other tasks, conditions, and task parameters. The current paper presents a live database that presents raw data from interval timing studies (currently composed of 68 datasets from eight different tasks incorporating various interval and temporal order judgments) with an online graphical user interface to easily select, compile, and download the data organized in a standard format. The Timing Database aims to promote and cultivate key and novel analyses of our timing ability by making published and future datasets accessible as open-source resources for the entire research community. In the current paper, we showcase the use of the database by testing various core ideas based on data compiled across studies (i.e., temporal accuracy, scalar property, location of the point of subjective equality, malleability of timing precision). The Timing Database will serve as the repository for interval timing studies through the submission of new datasets.Article Citation - WoS: 9Citation - Scopus: 9Numerical Averaging in Mice(Springer, 2020-11-04) Balcı, Fuat; Duyan, Yalcın Akın; Gür, EzgiRodents can be trained to associate different durations with different stimuli (e.g., light/sound). When the associated stimuli are presented together, maximal responding is observed around the average of individual durations (akin to averaging). The current study investigated whether mice can also average independently trained numerosities. Mice were initially trained to make 10 or 20 lever presses on a single (run) lever to obtain a reward and each fixed-ratio schedule was signaled either with an auditory or visual stimulus. Then, mice were trained to press another lever to obtain the reward after they responded on the run lever for the minimum number of presses [Fixed Consecutive Number (FCN)-10 or -20 trials] signaled by the corresponding discriminative stimulus. Following this training, FCN trials with the compound stimulus were introduced to test the counting behavior of mice when they encountered conflicting information regarding the number of responses required to obtain the reward. Our results showed that the numbers of responses on these compound test trials were around the average of the number of responses in FCN-10 and FCN-20 trials particularly when the auditory stimulus was associated with a fewer number of required responses. The counting strategy explained the behavior of the majority of the mice in the FCN-Compound test trials (as opposed to the timing strategy). The number of responses in FCN-Compound trials was accounted for equally well by the arithmetic, geometric, and Bayesian averages of the number of responses observed in FCN-10 and FCN-20 trials.Article Citation - WoS: 6Citation - Scopus: 6Health Outcomes Among Patients Diagnosed With Schizophrenia in the Us Veterans Health Administration Population Who Transitioned From Once-Monthly To Once-Every Paliperidone Palmitate: an Observational Retrospective Analysis(Springer, 2019-08-08) Khouyr, Antoine El; Wang, Li; Joshi, Kruti; Patel, Charmi; Başer, Onur; Huang, Ahong; El Khoury, AntoineThere is limited literature on treatment patterns, healthcare resource utilization (HRU), and costs among patients who transition from once-monthly paliperidone palmitate (PP1M) to once-every-3-month paliperidone palmitate (PP3M) in a real-world setting. Hence, this study compared treatment patterns, HRU, and costs 12-month pre- and post-PP3M transition among Veteran’s Health Administration (VHA) patients with schizophrenia.Article Citation - WoS: 18Citation - Scopus: 23Turkish Version of the Multidimensional Measure of Emotional Abuse: Preliminary Psychometrics in College Students(Springer, 2018) Hatipoğlu Sümer, Zeynep; Murphy, Christopher M.; Toplu Demirtaş, Ezgi; Sümer, Zeynep Hatipoglu; Demirtas, Ezgi TopluThe aim of the current study was to investigate the basic psychometrics of the Multidimensional Measure of Emotional Abuse (MMEA; Murphy & Hoover, 1999) in a Turkish sample. Two hundred and fifty-four college students participated and completed the Turkish version of the MMEA (MMEA-TR) along with the Physical Assault of Conflict Tactics Scale—Revised, Experiences in Close Relationships Inventory, Relationship Assessment Scale, and Social Desirability Questionnaire. Confirmatory factor analysis supported the four-factor structure of the MMEA-TR for both victimization and perpetration reports. This factor structure was cross-validated with an independent older sample of 328 dating college students for perpetration reports. Satisfactory criterion validity and internal consistency reliability results were obtained as well. Based on the preliminary investigation, the MMEA-TR appears to be a psychometrically sound measure of psychological dating aggression perpetration and victimization among college students in Turkey. The results, limitations, and recommendations for future studies were discussed.