PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1928
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Article Citation - WoS: 30Citation - Scopus: 29Out-Of Inr Values and Outcomes Among New Warfarin Patients With Non-Valvular Atrial Fibrillation(Springer, 2014-11-27) Schein, Jeffrey R; Wang, Li; Damaraju, Chandrasekharrao, V; Nelson, Winnie W; Başer, OnurBackground Although efficacious in stroke prevention in non-valvular atrial fibrillation, many warfarin patients are sub-optimally managed. Objective To evaluate the association of international normalized ratio control and clinical outcomes among new warfarin patients with non-valvular atrial fibrillation. Setting Adult non-valvular atrial fibrillation patients (a parts per thousand yen18 years) initiating warfarin treatment were selected from the US Veterans Health Administration dataset between 10/2007 and 9/2012. Method Valid international normalized ratio values were examined from the warfarin initiation date through the earlier of the first clinical outcome, end of warfarin exposure or death. Each patient contributed multiple in-range and out-of-range time periods. Main outcome measure The relative risk ratios of clinical outcomes associated with international normalized ratio control were estimated. Results 34,346 patients were included for analysis. During the warfarin exposure period, the incidence of events per 100 person-years was highest when patients had international normalized ratio < 2:13.66 for acute coronary syndrome; 10.30 for ischemic stroke; 2.93 for transient ischemic attack; 1.81 for systemic embolism; and 4.55 for major bleeding. Poisson regression confirmed that during periods with international normalized ratio < 2, patients were at increased risk of developing acute coronary syndrome (relative risk ratio: 7.9; 95 % confidence interval 6.9-9.1), ischemic stroke (relative risk ratio: 7.6; 95 % confidence interval 6.5-8.9), transient ischemic attack (relative risk ratio: 8.2; 95 % confidence interval 6.1-11.2), systemic embolism (relative risk ratio: 6.3; 95 % confidence interval 4.4-8.9) and major bleeding (relative risk ratio: 2.6; 95 % confidence interval 2.2-3.0). During time periods with international normalized ratio > 3, patients had significantly increased risk of major bleeding (relative risk ratio: 1.5; 95 % confidence interval 1.2-2.0). Conclusion In a Veterans Health Administration non-valvular atrial fibrillation population, exposure to out-of-range international normalized ratio values was associated with significantly increased risk of adverse clinical outcomes.Article Citation - WoS: 18Citation - Scopus: 23Turkish Version of the Multidimensional Measure of Emotional Abuse: Preliminary Psychometrics in College Students(Springer, 2018) Hatipoğlu Sümer, Zeynep; Murphy, Christopher M.; Toplu Demirtaş, Ezgi; Sümer, Zeynep Hatipoglu; Demirtas, Ezgi TopluThe aim of the current study was to investigate the basic psychometrics of the Multidimensional Measure of Emotional Abuse (MMEA; Murphy & Hoover, 1999) in a Turkish sample. Two hundred and fifty-four college students participated and completed the Turkish version of the MMEA (MMEA-TR) along with the Physical Assault of Conflict Tactics Scale—Revised, Experiences in Close Relationships Inventory, Relationship Assessment Scale, and Social Desirability Questionnaire. Confirmatory factor analysis supported the four-factor structure of the MMEA-TR for both victimization and perpetration reports. This factor structure was cross-validated with an independent older sample of 328 dating college students for perpetration reports. Satisfactory criterion validity and internal consistency reliability results were obtained as well. Based on the preliminary investigation, the MMEA-TR appears to be a psychometrically sound measure of psychological dating aggression perpetration and victimization among college students in Turkey. The results, limitations, and recommendations for future studies were discussed.