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https://hdl.handle.net/20.500.11779/1250
Title: | Risk of venous thromboembolism after new onset heart failure | Authors: | Smilowitz, Nathaniel R. Zhao, Qi Wang, Li Shrestha, Sulena Başer, Onur Berger, Jeffrey S. |
Keywords: | Deep-Vein Thrombosis Hospitalized-Patients American-College Mortality |
Publisher: | Nature Research | Source: | Smilowitz, N. R., Zhao, Q., Wang, L., Shrestha, S., Baser, O., & Berger, J. S. (December 01, 2019). Risk of Venous Thromboembolism after New Onset Heart Failure. Scientific Reports, 9, 1, 1-6. DOI: 10.1038/s41598-019-53641-0 | Abstract: | New-onset heart failure (HF) is associated with cardiovascular morbidity and mortality. It is uncertain to what extent HF confers an increased risk of venous thromboembolism (VTE). Adults >= 65 years old hospitalized with a new diagnosis of HF were identified from Medicare claims from 2007-2013. We identified the incidence, predictors and outcomes of VTE in HF. We compared VTE incidence during follow-up after HF hospitalization with a corresponding period 1-year prior to the HF diagnosis. Among 207,535 patients with a new HF diagnosis, the cumulative incidence of VTE was 1.4%, 2.5%, and 10.5% at 30 days, 1 year, and 5 years, respectively. The odds of VTE were greatest immediately after newonset HF and steadily declined over time (OR 2.2 [95% CI 2.0-2.3], OR 1.5 [1.4-1.7], and OR 1.2 [1.2-1.3] at 0-30 days, 4-6 months, and 7-9 months, respectively). Over 26-month follow-up, patients with HF were at two-fold higher risk of VTE than patients without HF (adjusted HR 2.31 [2.18-2.45]). VTE during follow-up was associated with long-term mortality (adjusted HR 1.60, 95% CI 1.56-1.64). In conclusion, patients with HF are at increased risk of VTE early after a new HF diagnosis. VTE in patients with HF is associated with long-term mortality. | URI: | https://hdl.handle.net/20.500.11779/1250 https://doi.org/10.1038/s41598-019-53641-0 |
ISSN: | 2045-2322 |
Appears in Collections: | Ekonomi Bölümü Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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RiskofVenousThromboembolism.pdf Until 2040-02-11 | Yayıncı Sürümü - Makale | 925.1 kB | Adobe PDF | View/Open Request a copy |
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