PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1928

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Citation - WoS: 9
Citation - Scopus: 8
A Longitudinal Assessment of Variability in Covid-19 Vaccine Hesitancy and Psychosocial Correlates in a National United States Sample
(Elsevier Sci Ltd, 2023) Shook, Natalie J.; Oosterhoff, Benjamin; Sevi, Barış
Recent evidence suggests that COVID-19 vaccine hesitancy is not static. In order to develop effective vaccine uptake interventions, we need to understand the extent to which vaccine hesitancy fluctuates and identify factors associated with both between- and within-person differences in vaccine hesitancy. The goals of the current study were to assess the extent to which COVID-19 vaccine hesitancy varied at an individual level across time and to determine whether disgust sensitivity and germ aversion were associated with between- and within-person differences in COVID-19 vaccine hesitancy. A national sample of U.S. adults (N = 1025; 516 woman; M-age = 46.34 years, SDage = 16.56, range: 18 to 85 years; 72.6 % White) completed six weekly online surveys (March 20 - May 3, 2020). Between-person mean COVID-19 vaccine hesitancy rates were relatively stable across the six-week period (range: 38-42 %). However, there was considerable within-person variability in COVID-19 vaccine hesitancy. Approximately, 40 % of the sample changed their vaccine hesitancy at least once during the six weeks. There was a significant between-person effect for disgust sensitivity, such that greater disgust sensitivity was associated with a lower likelihood of COVID-19 vaccine hesitance. There was also a significant within-person effect for germ aversion. Participants who experienced greater germ aversion for a given week relative to their own six week average were less likely to be COVID-19 vaccine hesitant that week relative to their own six-week average. This study provides important information on rapidly changing individual variability in COVID-19 vaccine hesitancy on a weekly basis, which should be taken into consideration with any efforts to decrease vaccine hesitancy and increase vaccine uptake. Further, these findings identify-two psychological factors (disgust sensitivity and germ aversion) with malleable components that could be leveraged in developing vaccine uptake interventions.
Citation - WoS: 12
Citation - Scopus: 15
Acoustic Streaming in a Soft Tissue Microenvironment
(Elsevier, 2019) El Ghamrawy, Ahmed; Mohammed, Ali; Jones, Julian R; Körük, Hasan; Choi, James J; de Comtes, Florentina
We demonstrated that sound can push fluid through a tissue-mimicking material. Although acousticstreaming in tissue has been proposed as a mechanism for biomedical ultrasound applications, such as neuromodu-lation and enhanced drug penetration, streaming in tissue or acoustic phantoms has not been directly observed. Wedeveloped a material that mimics the porous structure of tissue and used a dye and a video camera to track fluidmovement. When applied above an acoustic intensity threshold, a continuous focused ultrasound beam (spatialpeak time average intensity: 238 W/cm2, centre frequency: 5 MHz) was found to push the dye axially, that is, in thedirection of wave propagation and in the radial direction. Dye clearance increased with ultrasound intensity andwas modelled using an adapted version of Eckart’s acoustic streaming velocity equation. No microstructuralchanges were observed in the sonicated region when assessed using scanning electron microscopy. Our study indi-cates that acoustic streaming can occur in soft porous materials and provides a mechanistic basis for future use ofstreaming for therapeutic or diagnostic purposes.
Citation - WoS: 37
Citation - Scopus: 44
Adaptive Human Force Scaling Via Admittance Control for Physical Human-Robot Interaction
(IEEE, 2021) Başdoğan, Çağatay; Aydın, Yusuf; Hamad, Yahya M.
The goal of this article is to design an admittance controller for a robot to adaptively change its contribution to a collaborative manipulation task executed with a human partner to improve the task performance. This has been achieved by adaptive scaling of human force based on her/his movement intention while paying attention to the requirements of different task phases. In our approach, movement intentions of human are estimated from measured human force and velocity of manipulated object, and converted to a quantitative value using a fuzzy logic scheme. This value is then utilized as a variable gain in an admittance controller to adaptively adjust the contribution of robot to the task without changing the admittance time constant. We demonstrate the benefits of the proposed approach by a pHRI experiment utilizing Fitts’ reaching movement task. The results of the experiment show that there is a) an optimum admittance time constant maximizing the human force amplification and b) a desirable admittance gain profile which leads to a more effective co-manipulation in terms of overall task performance.
Citation - WoS: 18
Citation - Scopus: 18
Adding Rapid-Acting Insulin or Glp-1 Receptor Agonist To Basal Insulin: Outcomes in a Community Setting
(2015) Dalal, Mehul R; DiGenio, Andres; Xie, Lin; Başer, Onur
To evaluate real-world outcomes in patients with type 2 diabetes mellitus (T2DM)receiving basal insulin, who initiate add-on therapy with a rapid-acting insulin (RAI) or aglucagon-like peptide 1 (GLP-1) receptor agonist.Data were extracted retrospectively from a U.S. health claims database. Adults withT2DM on basal insulin who added an RAI (basal+RAI) or GLP-1 receptor agonist (basal+GLP-1) were included. Propensity score matching (1 up to 3 ratio) was used to control for differencesin baseline demographics, clinical characteristics, and health resource utilization. Endpointsincluded prevalence of hypoglycemia, pancreatic events, all-cause and diabetes-relatedresource utilization, and costs at 1 year follow-up. Overall, 6,718 matched patients were included: 5,013 basal+RAI and 1,705basal+GLP1. Patients in both groups experienced a similar proportion of any hypoglycemicevent (P = .4079). Hypoglycemic events leading to hospitalization were higher in the basal+RAIcohort (2.7% vs. 1.8%; P = .0444). The basal+GLP-1 cohort experienced fewer all-cause(13.55% vs. 18.61%; P<.0001) and diabetes-related hospitalizations (11.79% vs. 15.68%;P<.0001). The basal+GLP-1 cohort had lower total all-cause health care costs ($18,413 vs.$20,821; P = .0002), but similar diabetes-related costs ($9,134 vs. $8,985; P<.0001) comparedwith the basal+RAI cohort. Add-on therapy with a GLP-1 receptor agonist in T2DM patients receiving basalinsulin was associated with fewer hospitalizations and lower total all-cause costs compared withadd-on therapy using a RAI, and could be considered an alternative to a RAI in certain patientswith T2DM, who do not achieve effective glycemic control with basal insulin.
Citation - Scopus: 2
Brief Time Course of Trait Anxiety-Related Attentional Bias To Fearconditioned Stimuli: Evidence From the Dual-Rsvp Task
(Elsevier, 2016) Booth, Robert William
Background and objectives Attentional bias to threat is a much-studied feature of anxiety; it is typically assessed using response time (RT) tasks such as the dot probe. Findings regarding the time course of attentional bias have been inconsistent, possibly because RT tasks are sensitive to processes downstream of attention. Methods Attentional bias was assessed using an accuracy-based task in which participants detected a single digit in two simultaneous rapid serial visual presentation (RSVP) streams of letters. Before the target, two coloured shapes were presented simultaneously, one in each RSVP stream; one shape had previously been associated with threat through Pavlovian fear conditioning. Attentional bias was indicated wherever participants identified targets in the threat’s RSVP stream more accurately than targets in the other RSVP stream. Results In 87 unselected undergraduates, trait anxiety only predicted attentional bias when the target was presented immediately following the shapes, i.e. 160 ms later; by 320 ms the bias had disappeared. This suggests attentional bias in anxiety can be extremely brief and transitory. Limitations This initial study utilised an analogue sample, and was unable to physiologically verify the efficacy of the conditioning. The next steps will be to verify these results in a sample of diagnosed anxious patients, and to use alternative threat stimuli. Conclusions The results of studies using response time to assess the time course of attentional bias may partially reflect later processes such as decision making and response preparation. This may limit the efficacy of therapies aiming to retrain attentional biases using response time tasks.
Citation - WoS: 4
Citation - Scopus: 5
But the Poor Needed It More: Children's Judgments on Procedural Justice To Allocate Resources Between Two Candidates Equal in Merit, Different in Need
(Elsevier Science Inc, 2023) Sıvış, Özce; Acar, Melike
The current study investigated children's judgments on procedural justice and its outcomes when the candidates were equal in merit but different in need. A total of 88 children (41 girls and 47 boys) aged 7 to 11 years were individually interviewed (Mage = 8 years 9 months, SD = 14.065 months). Results showed that, regardless of age, children tended to give educational resources to the resource-poor candidates. However, children's welfare considera-tion of the resource-poor candidates increased with age. Children also made differentiated judgments based on the resource type and treated educational materials as more necessary than educa-tional experiences. Children's age and socioeconomic status (SES) were associated with this differentiation. Younger and high-SES children were more likely to view the outcome of procedural jus-tice (i.e., drawing a stick) for allocating an educational experience (i.e., summer camp) as fair when the result favored the resource -rich candidate. Overall, findings revealed that children do not use a unitary form of fairness in the procedural justice context. The shift from strict equality to welfare concerns continues to develop over middle childhood. (c) 2023 Elsevier Inc. All rights reserved.
Citation - WoS: 40
Citation - Scopus: 38
Clinical and Economic Burden Associated With Cardiovascular Events Among Patients With Hyperlipidemia: a Retrospective Cohort Study
(2016) Wang, Li; Quek, Ruben G. W; Fox, Kathleen M; Gandra, Shravanthi R; Li, Lu; Başer, Onur
Background: Annual direct costs for cardiovascular (CV) diseases in the United States are approximately $195.6 billion, with many high-risk patients remaining at risk for major cardiovascular events (CVE). This study evaluated the direct clinical and economic burden associated with new CVE up to 3 years post-event among patients with hyperlipidemia. Methods: Hyperlipidemic patients with a primary inpatient claim for new CVE (myocardial infarction, unstable angina, ischemic stroke, transient ischemic attack, coronary artery bypass graft, percutaneous coronary intervention and heart failure) were identified using IMS LifeLink PharMetrics Plus data from January 1, 2006 through June 30, 2012. Patients were stratified by CV risk into history of CVE, modified coronary heart disease risk equivalent, moderate-and low-risk cohorts. Of the eligible patients, propensity score matched 243,640 patients with or without new CVE were included to compare healthcare resource utilization and direct costs ranging from the acute (1-month) phase through 3 years post-CVE date (follow-up period). Results: Myocardial infarction was the most common CVE in all the risk cohorts. During the acute phase, among patients with new CVE, the average incremental inpatient length of stay and incremental costs ranged from 4.4-6.2 days and $25,666-$30,321, respectively. Acute-phase incremental costs accounted for 61-75 % of first-year costs, but incremental costs also remained high during years 2 and 3 post-CVE. Conclusions: Among hyperlipidemic patients with new CVE, healthcare utilization and costs incurred were significantly higher than for those without CVE during the acute phase, and remained higher up to 3 years post-event, across all risk cohorts.
Citation - WoS: 11
Citation - Scopus: 16
Consistency of Adults’ Earliest Memories Across Two Years
(Taylor & Francis, 2019) Gülgöz, Sami; Demiray, Burcu; Ece, Berivan
The consistency of earliest memories in content, dating, and memory qualities was investigated. A total of 84 (27 males; Mage = 24.93, SD = 1.36) adults reported earliest memories, estimated ages, and rated their recollections on memory qualities with a two-year time lag. At Time 2, their original reports at Time 1 were presented and they were asked to report whether the earliest memories they recalled at Time 2 were the same. Fifty-six per cent of the participants reported the same earliest memories and those remembering the same events had earlier memories than those remembering different ones. Although no significant differences were observed in estimated ages on the basis of mean ages, a predating bias of later memories and a tendency to postdate earlier memories were observed on the basis of a 48-month cut-off point. Thus, how the data is analysed is critical in detecting dating biases or errors affecting conclusions and interpretations about the dating consistency of earliest memories. Finally, memory qualities of earliest memories displayed a high level of consistency with a two-year time lag regardless of remembering the same versus different event.
Citation - WoS: 15
Citation - Scopus: 16
Does Cyber Dating Abuse Victimization Increase Depressive Symptoms or Vice Versa?
(SAGE Publications, 2020) Toplu-Demirtaş, Ezgi; Fincham, Frank D.; Seibert, Gregory S.; May, Ross W.
Although there is a robust positive association between cyber dating abuse victimization and depression, the direction of effects between them is unknown. Thus, we conducted two studies to investigate their temporal relationship. Study 1 (n = 198) examined whether cyber dating abuse victimization predicted depressive symptoms 6 weeks later, after controlling for the initial level of depressive symptoms. Study 2 (n = 264) used a two-wave, cross-lagged design to investigate possible bidirectional relations between cyber dating abuse victimization and depression. Participants in both studies were emerging adults in romantic relationships. They completed the Partner Cyber Abuse Questionnaire and depression subscale of the Depression Anxiety and Stress Scale. Many individuals (42.40% in Study 1 and 36.4% in Study 2) reported experiencing cyber abuse from their partners. Study 1 replicated the cross-sectional association previously found between cyber dating abuse victimization and depression and showed that cyber abuse predicted depression 6 weeks later. Study 2 replicated the findings of the first study and revealed that cyber dating abuse victimization was related to higher levels of depressive symptoms 12 weeks later, but the converse was not the case. These results are discussed in terms of their implications for future research and clinical practice.
Citation - WoS: 12
Citation - Scopus: 14
Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force
(Elsevier, 2020) Körük, Hasan; Bezer, James H.; J Rowlands, Christopher; Choi, James J.
Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25–100 µm, Young's modulus: 2–8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6–1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading–unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
Citation - WoS: 12
Citation - Scopus: 14
Emotional Dependency and Dysfunctional Relationship Beliefs as Predictors of Married Turkish Individuals’ Relationship Satisfaction
(Cambridge University Press, 2016) Çetinkaya Yıldız, Evrim; Kemer, Gülşah; Bulgan, Gökçe
In this study, we examined married individuals’ relationship satisfaction in relation to their emotional dependency and dysfunctional relationship beliefs. Our participants consisted of 203 female and 181 male, a total of 384 married individuals from urban cities of Turkey. Controlling the effects of gender and length of marriage, we performed a hierarchical regression analysis. Results revealed that married Turkish individuals’ relationship satisfaction was significantly explained by their emotional dependency (sr2 = .300, p < .001), and perceptions of interpersonal rejection (sr2 = .075, p < .001) and unrealistic relationship expectations (sr2 = .028, p < .001). However, interpersonal misperception did not make a significant contribution to the participants’ relationship satisfaction (p > .05). When compared to perceptions of interpersonal rejection and unrealistic relationship expectations, emotional dependency had the largest role in explaining participants’ satisfaction with their marriages. We discuss the results in light of current literature as well as cultural relevance. We also provide implications for future research and mental health practices.
Citation - WoS: 4
Citation - Scopus: 5
Feeling Guilt and Shame Upon Psychological Dating Violence Victimization in College Women : the Further Role of Sexism
(SAGE Publications, 2022) Fincham, D. Frank; Demirtaş, Toplu Ezgi; Öztemür, Gizem; Oflaz, Çiğdem
Dating violence is manifested in different forms between romantic partners. Psychological violence, the most common form of dating violence, is more likely to affect women, eliciting feelings such as shame and guilt. The robust relationship of sexism to psychological dating violence victimization (PDVV) is well-documented but whether PDVV serves as a mechanism linking sexism to guilt and shame remains unexplored. This study, therefore, investigated the potential mediating role of PDVV in the association between sexist attitudes and feelings of guilt and shame. Dating college women (N = 219) from Turkey, an honor culture in which one’s self-worth lies on one’s evaluation as well as the assessment of what others think, participated in the study. High rates of PDVV were found in this culture, and structural equation modeling revealed that PDVV mediated the relationship between sexism and feelings of guilt and shame. These findings are discussed in terms of their implications for future research and how sexist attitudes might be challenged to reduce the adverse emotional effects experienced by women who are victims of psychological dating violence.
Citation - WoS: 20
Citation - Scopus: 17
Feelings of Burden Among Family Caregivers of People With Spinal Cord Injury in Turkey
(Springer Nature, 2017) Yavuz, H. Melis; Selçuk, Bilge; Seçinti, Ekin
Study design: The study was designed as a cross-sectional survey. Objectives: The purpose of the study was to examine the level of feelings of burden in family caregivers of people with spinal cord injury (SCI) in Turkey, and to explore its predictors. Setting: Turkey. Methods: One hundred family caregivers of people with SCI completed measures of burden of caregiving, depression, social support and physical health. The SCI participants completed a measure of functional independence. Multivariate statistics and structural equation modeling (SEM) were conducted to identify significant predictors of caregiver burden. Results: Caregiver burden was significantly related to caregivers’ feelings of depression. SEM analysis showed that social support from family and from friends predicted caregiver burden via depression. Caregivers’ age, sex, educational level, physical health and household income did not significantly predict their feelings of depression or burden. Conclusions: Our findings revealed that support received from both families and friends is an important source for alleviating the depressive feelings of caregivers and, in return, their burden in the caregiving. In Turkey, high support from family members is expected and is important for psychological well-being, yet the current study showed that the support received from friends also has unique contribution to the well-being of the caregivers of persons with SCI. Overall, our findings highlight the importance of supportive relationships between family as well as friends for the caregivers who may have to provide lifetime care for their family member with special needs.
Citation - WoS: 6
Citation - Scopus: 7
Hematocrit Levels and Thrombotic Events in Patients With Polycythemia Vera: an Analysis of Veterans Health Administration Data
(Springer, 2019) Parasuraman, Shreekant; Robyn Scherber; Jingbo Yu; Li Wang; Dilan Paranagama; Sulena Shrestha; Başer, Onur
Patients with polycythemia vera (PV) have a high incidence of thrombotic events (TEs), contributing to a greater mortality risk than the general population. The relationship between hematocrit (HCT) levels and TE occurrence among patients with PV from the Veterans Health Administration (VHA) was evaluated to replicate findings of the CYTO-PV trial with a real-world patient population. This retrospective study used VHA medical record and claims data from the first claim with a PV diagnosis (index) until death, disenrollment, or end of study, collected between October 1, 2005, and September 30, 2012. Patients were aged ? 18 years at index, had ? 2 claims for PV (ICD-9-CM code, 238.4) ? 30 days apart during the identification period, continuous health plan enrollment from 12 months pre-index until end of study, and ? 3 HCT measurements per year during follow-up. This analysis focused on patients with no pre-index TE, and with all HCT values either < 45% or ? 45% during the follow-up period. The difference in TE risk between HCT groups was assessed using unadjusted Cox regression models based on time to first TE. Patients (N = 213) were mean (SD) age 68.9 (11.5) years, 98.6% male, and 61.5% white. TE rates for patients with HCT values < 45% versus ? 45% were 40.3% and 54.2%, respectively. Among patients with ? 1 HCT before TE, TE risk hazard ratio was 1.61 (95% CI, 1.03–2.51; P = 0.036). This analysis of the VHA population further supports effective monitoring and control of HCT levels < 45% to reduce TE risk in patients with PV.
Citation - WoS: 18
Citation - Scopus: 20
I Don't Have Power, and I Want More: Psychological, Physical, and Sexual Dating Violence Perpetration Among College Students
(SAGE Publications, 2020) Fincham, Frank D.; Toplu Demirtaş, Ezgi
The purpose of this study was to (a) explore the prevalence of, and gender differences in, self-reported physical, sexual, and psychological violence perpetration in dating relationships (i.e., not married or engaged), (b) evaluate the factorial validity of the Power Perceptions and Power Satisfaction Questionnaire in dating relationships, and (c) document the mediating role of power satisfaction in the associations between power perception and physical, sexual, and psychological dating violence perpetration. College students (N= 812) completed the Power Perceptions and Power Satisfaction Questionnaire and the Psychological Aggression, Physical Assault, and Sexual Coercion subscales of the Revised Conflict Tactics Scale. Gender differences emerged in the prevalence of physical (43.0% for women and 35.0% for men) and sexual violence (25.0% for women and 41.8% for men) but not psychological violence (80.1% for women and 75.5% for men). Exploratory factor and parallel analyses yielded two subscales of power perceptions and power satisfaction, which explained 40.56% of the variance. Mediation analyses revealed that college students who perceived lower relationship power were more dissatisfied with that relationship power and, in turn, perpetrated more physical, sexual, and psychological violence against their partners. The mediation effects were evident in both women and men. The implications of the current findings for future research and mental health professionals at colleges are outlined.
Citation - WoS: 10
Citation - Scopus: 12
I Ruminate Therefore I Violate: the Tainted Love of Anxiously Attached and Jealous Partners
(SAGE Publications, 2020) Aracı-İyiaydın, Ayşegül; Toplu-Demirtaş, Ezgi; Fincham, Frank D.; Akçabozan-Kayabol, Nazlı Büşra
Anxiously attached individuals worry about the psychological availability of their partners. Their preoccupation with unmet attachment related needs is likely accompanied by ruminative thoughts, feelings of jealousy, and dating abuse perpetration. The purpose of the current study was to investigate the prevalence of gender differences in perpetrating psychological and cyber dating abuse and to explore a hypothesized serial path from anxious attachment, through rumination, and cognitive jealousy to psychological and cyber dating abuse perpetration. The sample consisted of 562 (404 women) Turkish emerging adults. The majority of the sample perpetrated at least one psychological (88.9%) and cyber (68.4%) abusive behavior over the last six months, with women perpetrating more psychological and cyber abuse. We tested a serial mediational model for each type of dating abuse, which indicated that anxious attachment was related to more rumination (brooding), cognitive jealousy, and in turn, to psychological and cyber dating abuse perpetration. We discuss the implications of our study for research, theory, and practice.
Citation - WoS: 25
Citation - Scopus: 25
Impact of Switching From an Initial Tumor Necrosis Factor Inhibitor on Health Care Resource Utilization and Costs Among Patients With Rheumatoid Arthritis
(2015) Roy, Sanjoy; Ganguli, Arijit; Xie, Lin; Başer, Onur; Cifaldi, Mary
Purpose: Despite improved clinical outcomes for the majority of patients, nearly 30% of patients with rheumatoid arthritis (RA) who initiate tumor necrosis factor antagonist (anti-TNF) biologic agents fail to respond to their first-line anti-TNF and switch to another anti-TNF or a non-TNF biologic. How this change affects health care costs and resource utilization is unknown. We therefore compared RA patients taking first-line anti-TNFs who switched to a second anti-TNF versus those patients who switched to an alternate biologic. Methods: Health care claims data were obtained from a large US database for eligible adults with confirmed RA diagnoses who initiated anti-TNF treatment and switched to another biologic. Health care costs and utilization during the first 12 months' postswitch were compared. Generalized linear models were used to adjust for differences in demographic and clinical characteristics before switching. Findings: Patients who switched to a second anti-TNF rather than a non-TNF biologic were generally younger (53.0 vs. 55.3 years; P < 0.0001) and less likely to be female (79.7% vs. 82.7%; P = 0.0490). Of the 3497 eligible patients who switched from first-line anti-TNFs, 2563 (73.3%) switched to another anti-TNF and 934 (26.7%) switched to a non-TNF. Adalimumab was the most frequently prescribed (43.4%) second-line anti-TNF, and abatacept was the most common non anti-TNF (71.4%). Patients who switched to a second anti-TNF remained on their first medication for a significantly shorter period (342.5 vs 420.6 days; P < 0.0001) and had lower comorbidity indices and higher disease severity at baseline than those who switched to a non anti-TNF. After adjusting for baseline differences, patients who switched to second anti-TNFs versus a non-TNF incurred lower RA-related costs ($20,938.9 vs $22,645.2; P = 0.0010) and total health care costs ($34,894.6 vs $38,437.2; P = 0.0010) 1 year postswitch. These differences were driven by increased physician office visit costs among the non-TNF group. Implications: Among the anti-TNF initiators who switched therapy, more patients switched to a second anti-TNF than to a non-TNF. Switching to a second anti-TNF treatment was associated with lower all-cause and RA-related health care costs and resource utilization than switching to a non-TNF. Because switching therapy may be unavoidable, finding a treatment algorithm mitigating this increase to any extent should be considered. These data are limited by their retrospective design. Additional confounding variables that could not be controlled for may affect results. (C) 2015 The Authors. Published by Elsevier HS journals, Inc.
Linking Obsessions To Morality: a Cross-Cultural Study Among Turkish and Belgian University Students
(Sage Publications Ltd, 2024) Özcanlı, Fulya; Claes, Laurence; Hermans, Dirk; Mesquita, Batja
The present study examines the links between different types of morality and obsessions in university students from Leuven, Belgium (N = 252) and & Idot;stanbul, Turkey (N = 301) using validated scales for morality and obsessions. Belgium and Turkey were chosen as two exemplar cultural contexts expected, and in the current study found, to differ in the relative levels of individualizing and binding morality. We hypothesized that obsessions involving potential harm (e.g., aggressive obsessions) are cross-culturally associated with individualizing morals, and obsessions indicating impurity (e.g., contamination) are cross-culturally associated with binding morals. Moreover, we expected that cultural differences in the frequency of obsessions could be linked to differences in culturally prevalent moralities. As predicted, contamination obsessions were cross-culturally linked to binding morals. Also, the frequency of contamination obsessions was higher in the Turkish sample compared to the Belgian, which was predicted by higher levels of binding morals in Turkey. Doubts were cross-culturally endorsed at similar rates and were associated with individualizing morals. Aggressive obsessions were relatively more frequent in the Belgian compared to the Turkish sample, however-unexpectedly-these intrusions were not positively linked to either type of morality, neither in Belgium nor in Turkey. Taken together, these findings provide initial support for the role of morality in obsessive-compulsive disorder (OCD), at least for certain types of obsessions (contamination and doubts), as well as suggest that some differences in the moral foundations may play a role in explaining the prevalence of certain obsessions (i.e., contamination).
Making the Myths of Dating Violence Visible: Developing a New Scale and Testing Its Psychometrics Through Cross-Sectional and Longitudinal Evidence
(Sage Publications Inc, 2023) Aracı-İyiaydın, Ayşegül; Toplu-Demirtaş, Ezgi; Mesut, Cansel; Soysal, Demet Esra
Myths refer to misperceptions, overgeneralizations, or ideas that most people believe in but do not necessarily reflect the truth. To date, research on the myths surrounding dating violence (DV) has not received much attention, most probably due to the lack of a validated measure. Thus, we developed a standardized measure to gauge DV myths and test its psychometrics. The instrument's design is based on three studies utilizing cross-sectional and longitudinal sets of data. In Study 1, in a sample of 259 emerging adults, predominantly college students, the explanatory factor analysis revealed a solid three-factor structure. In Study 2, in a separate sample of 330 emerging adults, primarily college students, we cross-validated the factor structure via confirmatory factor analysis. We also provided evidence for concurrent validity. In Study 3, we revealed that our newly developed scale had predictive validity among dating and non-dating emerging adults, mostly college students, via longitudinal data. Based on the findings from three studies, we can buoyantly announce that the Dating Violence Myths scale is a promising novel and standardized tool for measuring beliefs about DV. The cross-sectional and longitudinal evidence alludes to a need for DV myths to be debunked to reduce psychological DV attitudes, perceptions, and behaviors among emerging adults.
Citation - WoS: 2
Citation - Scopus: 2
Mice Make Temporal Inferences About Novel Locations Based on Previously Learned Spatiotemporal Contingencies
(Springer, 2022) Balci, Fuat; Gür, Ezgi; Duyan, Yalçin A.
Animals learn multiple spatiotemporal contingencies and organize their anticipatory responses accordingly. The representational/computational capacity that underlies such spatiotemporally guided behaviors is not fully understood. To this end, we investigated whether mice make temporal inferences of novel locations based on previously learned spatiotemporal contingencies. We trained 18 C57BL/6J mice to anticipate reward after three different intervals at three different locations and tested their temporal expectations of a reward at five locations simultaneously, including two locations that were not previously associated with reward delivery but adjacent to the previously trained locations. If mice made spatiotemporal inferences, they were expected to interpolate between duration pairs associated with previously reinforced hoppers surrounding the novel hopper. We found that the maximal response rate at the novel locations indeed fell between the two intervals reinforced at the surrounding hoppers. We argue that this pattern of responding might be underlain by spatially constrained Bayesian computations.

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