PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1928

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Now showing 1 - 20 of 48

Citation - WoS: 9
Citation - Scopus: 8
A Longitudinal Assessment of Variability in Covid-19 Vaccine Hesitancy and Psychosocial Correlates in a National United States Sample
(Elsevier Sci Ltd, 2023) Shook, Natalie J.; Oosterhoff, Benjamin; Sevi, Barış
Recent evidence suggests that COVID-19 vaccine hesitancy is not static. In order to develop effective vaccine uptake interventions, we need to understand the extent to which vaccine hesitancy fluctuates and identify factors associated with both between- and within-person differences in vaccine hesitancy. The goals of the current study were to assess the extent to which COVID-19 vaccine hesitancy varied at an individual level across time and to determine whether disgust sensitivity and germ aversion were associated with between- and within-person differences in COVID-19 vaccine hesitancy. A national sample of U.S. adults (N = 1025; 516 woman; M-age = 46.34 years, SDage = 16.56, range: 18 to 85 years; 72.6 % White) completed six weekly online surveys (March 20 - May 3, 2020). Between-person mean COVID-19 vaccine hesitancy rates were relatively stable across the six-week period (range: 38-42 %). However, there was considerable within-person variability in COVID-19 vaccine hesitancy. Approximately, 40 % of the sample changed their vaccine hesitancy at least once during the six weeks. There was a significant between-person effect for disgust sensitivity, such that greater disgust sensitivity was associated with a lower likelihood of COVID-19 vaccine hesitance. There was also a significant within-person effect for germ aversion. Participants who experienced greater germ aversion for a given week relative to their own six week average were less likely to be COVID-19 vaccine hesitant that week relative to their own six-week average. This study provides important information on rapidly changing individual variability in COVID-19 vaccine hesitancy on a weekly basis, which should be taken into consideration with any efforts to decrease vaccine hesitancy and increase vaccine uptake. Further, these findings identify-two psychological factors (disgust sensitivity and germ aversion) with malleable components that could be leveraged in developing vaccine uptake interventions.
Citation - WoS: 23
Citation - Scopus: 25
Acoustic Particle Palpation for Measuring Tissue Elasticity
(American Institute of Physics, 2015) El Ghamrawy, Ahmed; Körük, Hasan; Choi, James J; Pouliopoulos, Antonios N
We propose acoustic particle palpation—the use of sound to press a population of acoustic particles against an interface—as a method for measuring the qualitative and quantitative mechanical properties of materials. We tested the feasibility of this method by emitting ultrasound pulses across a tunnel of an elastic material filled with microbubbles. Ultrasound stimulated the microbubble cloud to move in the direction of wave propagation, press against the distal surface, and cause deformations relevant for elasticity measurements. Shear waves propagated away from the palpation site with a velocity that was used to estimate the material’s Young’s modulus.
Citation - WoS: 12
Citation - Scopus: 15
Acoustic Streaming in a Soft Tissue Microenvironment
(Elsevier, 2019) El Ghamrawy, Ahmed; Mohammed, Ali; Jones, Julian R; Körük, Hasan; Choi, James J; de Comtes, Florentina
We demonstrated that sound can push fluid through a tissue-mimicking material. Although acousticstreaming in tissue has been proposed as a mechanism for biomedical ultrasound applications, such as neuromodu-lation and enhanced drug penetration, streaming in tissue or acoustic phantoms has not been directly observed. Wedeveloped a material that mimics the porous structure of tissue and used a dye and a video camera to track fluidmovement. When applied above an acoustic intensity threshold, a continuous focused ultrasound beam (spatialpeak time average intensity: 238 W/cm2, centre frequency: 5 MHz) was found to push the dye axially, that is, in thedirection of wave propagation and in the radial direction. Dye clearance increased with ultrasound intensity andwas modelled using an adapted version of Eckart’s acoustic streaming velocity equation. No microstructuralchanges were observed in the sonicated region when assessed using scanning electron microscopy. Our study indi-cates that acoustic streaming can occur in soft porous materials and provides a mechanistic basis for future use ofstreaming for therapeutic or diagnostic purposes.
Citation - WoS: 18
Citation - Scopus: 18
Adding Rapid-Acting Insulin or Glp-1 Receptor Agonist To Basal Insulin: Outcomes in a Community Setting
(2015) Dalal, Mehul R; DiGenio, Andres; Xie, Lin; Başer, Onur
To evaluate real-world outcomes in patients with type 2 diabetes mellitus (T2DM)receiving basal insulin, who initiate add-on therapy with a rapid-acting insulin (RAI) or aglucagon-like peptide 1 (GLP-1) receptor agonist.Data were extracted retrospectively from a U.S. health claims database. Adults withT2DM on basal insulin who added an RAI (basal+RAI) or GLP-1 receptor agonist (basal+GLP-1) were included. Propensity score matching (1 up to 3 ratio) was used to control for differencesin baseline demographics, clinical characteristics, and health resource utilization. Endpointsincluded prevalence of hypoglycemia, pancreatic events, all-cause and diabetes-relatedresource utilization, and costs at 1 year follow-up. Overall, 6,718 matched patients were included: 5,013 basal+RAI and 1,705basal+GLP1. Patients in both groups experienced a similar proportion of any hypoglycemicevent (P = .4079). Hypoglycemic events leading to hospitalization were higher in the basal+RAIcohort (2.7% vs. 1.8%; P = .0444). The basal+GLP-1 cohort experienced fewer all-cause(13.55% vs. 18.61%; P<.0001) and diabetes-related hospitalizations (11.79% vs. 15.68%;P<.0001). The basal+GLP-1 cohort had lower total all-cause health care costs ($18,413 vs.$20,821; P = .0002), but similar diabetes-related costs ($9,134 vs. $8,985; P<.0001) comparedwith the basal+RAI cohort. Add-on therapy with a GLP-1 receptor agonist in T2DM patients receiving basalinsulin was associated with fewer hospitalizations and lower total all-cause costs compared withadd-on therapy using a RAI, and could be considered an alternative to a RAI in certain patientswith T2DM, who do not achieve effective glycemic control with basal insulin.
Citation - WoS: 17
Citation - Scopus: 23
Benefit of Early Discharge Among Patients With Low-Risk Pulmonary Embolism
(2017) Wang, Li; Wells, Phil; Fermann, Gregory J; Peacock, W. Frank; Schein, Jeff; Coleman, Craig I; Crivera, Concetta; Başer, Onur
Clinical guidelines recommend early discharge of patients with low-risk pulmonary embolism (LRPE). This study measured the overall impact of early discharge of LRPE patients on clinical outcomes and costs in the Veterans Health Administration population. Adult patients with >= 1 inpatient diagnosis for pulmonary embolism (PE) (index date) between 10/2011-06/2015, continuous enrollment for >= 12 months pre-and 3 months post-index date were included. PE risk stratification was performed using the simplified Pulmonary Embolism Stratification Index. Propensity score matching (PSM) was used to compare 90-day adverse PE events (APEs) [recurrent venous thromboembolism, major bleed and death], hospital-acquired complications (HACs), healthcare utilization, and costs among short (<= 2 days) versus long length of stay (LOS). Net clinical benefit was defined as 1 minus the combined rate of APE and HAC. Among 6,746 PE patients, 95.4% were men, 22.0% were African American, and 1,918 had LRPE. Among LRPE patients, only 688 had a short LOS. After 1:1 PSM, there were no differences in APE, but short LOS had fewer HAC (1.5% vs 13.3%, 95% CI: 3.77-19.94) and bacterial pneumonias (5.9% vs 11.7%, 95% CI: 1.24-3.23), resulting in better net clinical benefit (86.9% vs 78.3%, 95% CI: 0.84-0.96). Among long LOS patients, HACs (52) exceeded APEs (14 recurrent DVT, 5 bleeds). Short LOS incurred lower inpatient ($2,164 vs $5,100, 95% CI: $646.8-$5225.0) and total costs ($9,056 vs $12,544, 95% CI: $636.6-$6337.7). LRPE patients with short LOS had better net clinical outcomes at lower costs than matched LRPE patients with long LOS.
Body Appreciation Matters: The Associations Between Self-Compassion, Body Appreciation, and Disordered Eating Behaviors Among Heterosexual and LGBi Plus Emerging Adults in Türkiye
(Sage Publications inc, 2025) Deveci, Ayse Nur; Demirtas, Ezgi Toplu; Bulgan, Gokce
Objectives: Self-compassion has been effective in the prevention and treatment of disordered eating behaviors and body image issues, which are significant public health concerns with potential psychosocial and physical consequences. Furthermore, there remains a substantial gap in the existing body of research, particularly in the context of heterosexual, lesbian, gay, and bisexual plus (LGBi+) emerging adults in T & uuml;rkiye. Therefore, this study aims to explore the mediating role of body appreciation in the relationship between self-compassion and disordered eating behaviors and the moderating role of sexual orientation (heterosexual and LGBi+) in the mediation among emerging adults. Methods: A diverse sample of participants comprising heterosexual (n = 242) and LGBi+ (n = 204) emerging adults (Mage = 22.18; SDage = 3.07; min = 18; max = 30) completed self-report measures of the Self-Compassion Scale, Body Appreciation Scale-2, and Eating Attitude Test-26. Results: The results of moderated meditation revealed that body appreciation mediated the relationship between self-compassion and disordered eating behaviors among both heterosexual and LGBi+ individuals. Conclusions: The findings may inform support strategies and interventions to reduce eating disorder risk and promote mental health and well-being in both heterosexual and LGBi+ populations by emphasizing self-compassion and body appreciation.
Citation - WoS: 4
Citation - Scopus: 5
But the Poor Needed It More: Children's Judgments on Procedural Justice To Allocate Resources Between Two Candidates Equal in Merit, Different in Need
(Elsevier Science Inc, 2023) Sıvış, Özce; Acar, Melike
The current study investigated children's judgments on procedural justice and its outcomes when the candidates were equal in merit but different in need. A total of 88 children (41 girls and 47 boys) aged 7 to 11 years were individually interviewed (Mage = 8 years 9 months, SD = 14.065 months). Results showed that, regardless of age, children tended to give educational resources to the resource-poor candidates. However, children's welfare considera-tion of the resource-poor candidates increased with age. Children also made differentiated judgments based on the resource type and treated educational materials as more necessary than educa-tional experiences. Children's age and socioeconomic status (SES) were associated with this differentiation. Younger and high-SES children were more likely to view the outcome of procedural jus-tice (i.e., drawing a stick) for allocating an educational experience (i.e., summer camp) as fair when the result favored the resource -rich candidate. Overall, findings revealed that children do not use a unitary form of fairness in the procedural justice context. The shift from strict equality to welfare concerns continues to develop over middle childhood. (c) 2023 Elsevier Inc. All rights reserved.
Determining the Effect of Video Information on the Dental Anxiety Levels of the Endodontic Patients: a Randomised Clinical Trial
(Wiley, 2025) Anatürk, Şule; Dönmez Özkan, Hicran; Saral, İlkim Pınar; Çakar, Tuna
Objective The present study assessed the effectiveness of pretreatment education in the form of Visual Video Information (VVI) on the anxiety levels of patients during endodontic treatment steps. Methods Patients (n = 120) having single-rooted teeth with a single root canal diagnosed with asymptomatic irreversible pulpitis and/or pre-prosthetic root canal treatment were included in this study. After completing anxiety scales and a sociodemographic/dental habits survey, the patients were randomly divided into two groups. Just before the endodontic treatment, VVI was given to the video group patients, while the control group patients received routine information verbally. In both groups, a galvanic skin response (GSR) device was placed on the patients' wrists to record the stress levels during the endodontic treatment process. Anxiety scales and a feedback-satisfaction survey were administered to all patients after the treatment process. Then, statistical analysis was performed (alpha = 0.05). Results This study performed 60 endodontic treatments on 60 patients (30 females and 30 males). Sociodemographic characteristics and dental treatment habits of the patients significantly affected dental anxiety scale scores (p < 0.05). VVI resulted in a significant decrease in the mean scores of anxiety before and after the treatment, but this decrease was not significant between the groups (p > 0.05). Similarly, VVI did not impact the GSR readings between the groups during treatment (p > 0.05). Conclusions The educational VVI is effective for reducing anxiety in patients undergoing endodontic treatment. In addition, the electrodermal activity method is a promising alternative for objectively assessing anxiety levels.
Citation - WoS: 10
Citation - Scopus: 13
Displacement of a Bubble by Acoustic Radiation Force Into a Fluid-Tissue Interface
(2018) Körük, Hasan; Choi, James J
Microbubbles in an ultrasound beam experience a primary Bjerknes force, which pushes the microbubbles against a fluid-tissue interface and deforms the tissue. This interaction has been used to measure tissue elasticity and is a common interaction in many therapeutic and diagnostic applications, but the mechanisms of deformation, and how the deformation dynamic depends on the bubble and ultrasound parameters, remain unknown. In this study, a mathematical model is proposed for the displacement of a bubble onto a fluid-tissue interface and the tissue deformation in response to the primary Bjerknes force. First, a model was derived for static loading and the model's prediction of bubble-mediated tissue displacement and stresses in tissue were explored. Second, the model was updated for dynamic loading. The results showed that the bubble is both displaced by the applied force and changes its shape. The bubble displacement changes nonlinearly with the applied force. The stress values in tissue are quite high for a distance within one radius of the bubble from the bubble surface. The model proposed here is permissible in human tissue and can be used for biomedical ultrasound applications, including material characterization. (C) 2018 Acoustical Society of America.
Citation - WoS: 15
Citation - Scopus: 16
Does Cyber Dating Abuse Victimization Increase Depressive Symptoms or Vice Versa?
(SAGE Publications, 2020) Toplu-Demirtaş, Ezgi; Fincham, Frank D.; Seibert, Gregory S.; May, Ross W.
Although there is a robust positive association between cyber dating abuse victimization and depression, the direction of effects between them is unknown. Thus, we conducted two studies to investigate their temporal relationship. Study 1 (n = 198) examined whether cyber dating abuse victimization predicted depressive symptoms 6 weeks later, after controlling for the initial level of depressive symptoms. Study 2 (n = 264) used a two-wave, cross-lagged design to investigate possible bidirectional relations between cyber dating abuse victimization and depression. Participants in both studies were emerging adults in romantic relationships. They completed the Partner Cyber Abuse Questionnaire and depression subscale of the Depression Anxiety and Stress Scale. Many individuals (42.40% in Study 1 and 36.4% in Study 2) reported experiencing cyber abuse from their partners. Study 1 replicated the cross-sectional association previously found between cyber dating abuse victimization and depression and showed that cyber abuse predicted depression 6 weeks later. Study 2 replicated the findings of the first study and revealed that cyber dating abuse victimization was related to higher levels of depressive symptoms 12 weeks later, but the converse was not the case. These results are discussed in terms of their implications for future research and clinical practice.
Citation - WoS: 13
Citation - Scopus: 14
Economic Outcomes in Patients With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Treated With Enzalutamide or Abiraterone Acetate Plus Prednisone
(Springer, 2020) Lechpammer, Stanislav; Ramaswamy, Krishnan; Wang, Li; Mardekian, Jack; George, Daniel J.; Sandin, Rickard; Schultz, Neil M.; Başer, Onur; Huang, Ahong
Introduction: Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naı¨ve metastatic castration-resistant PC (mCRPC) treated with enzalutamide or abiraterone acetate plus prednisone (abiraterone). Methods: We performed a retrospective analysis on 3174 men (18 years or older) utilizing the Veterans Health Administration (VHA) database from 1 April 2014 to 31 March 2018. Men with mCRPC were included if they had at least one pharmacy claim for enzalutamide or abiraterone (ﬁrst claim date = index date) following surgical or medical castration, had no chemotherapy treatment within 12 months prior to the index date, and had continuous VHA enrollment for at least 12 months pre- and post-index date. Men were followed until death, disenrollment, or end of study and were 1:1 propensity score matched (PSM). All-cause and PC-related resource use and costs per patient per month (PPPM) in the 12 months post index were compared between matched cohorts. Results: We identiﬁed 1229 men with mCRPC prescribed enzalutamide and 1945 prescribed abiraterone with mean ages of 74 and 73 years, respectively. After PSM, each cohort had 1160 patients. The enzalutamide cohort had fewer all-cause (2.51 vs 2.86; p\0.0001) and PC-related outpatient visits (0.86 vs 1.03; p\0.0001), with corresponding lower all-cause ($2588 vs $3115; p\0.0001) and PC-related ($1356 vs $1775; p\0.0001) PPPM outpatient costs compared with the abiraterone cohort. Allcause total costs (medical and pharmacy) PPPM ($8085 vs $9092; p = 0.0002) and PC-related total costs PPPM ($6321 vs $7280; p\0.0001) were signiﬁcantly lower in the enzalutamide cohort compared with the abiraterone cohort. Conclusions: Enzalutamide-treated men with chemotherapy-naı ¨ve mCRPC had signiﬁcantly lower resource utilization and healthcare costs compared with abiraterone-treated men. Plain Language Summary: Plain language summary available for this article.
Citation - WoS: 3
Citation - Scopus: 3
Effects of Vaccination and the Spatio-Temporal Diffusion of Covid-19 Incidence in Turkey
(John Wiley and Sons Inc, 2022) Bilgel, Fırat; Karahasan, Burhan Can
This study assesses the spatio-temporal impact of vaccination efforts on Covid-19 incidence growth in Turkey. Incorporating geographical features of SARS-CoV-2 transmission, we adopt a spatial Susceptible–Infected–Recovered (SIR) model that serves as a guide of our empirical specification. Using provincial weekly panel data, we estimate a dynamic spatial autoregressive (SAR) model to elucidate the short- and the long-run impact of vaccination on Covid-19 incidence growth after controlling for temporal and spatio-temporal diffusion, testing capacity, social distancing behavior and unobserved space-varying confounders. Results show that vaccination growth reduces Covid-19 incidence growth rate directly and indirectly by creating a positive externality over space. The significant association between vaccination and Covid-19 incidence is robust to a host of spatial weight matrix specifications. Conspicuous spatial and temporal diffusion effects of Covid-19 incidence growth were found across all specifications: the former being a severer threat to the containment of the pandemic than the latter.
Citation - WoS: 12
Citation - Scopus: 14
Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force
(Elsevier, 2020) Körük, Hasan; Bezer, James H.; J Rowlands, Christopher; Choi, James J.
Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25–100 µm, Young's modulus: 2–8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6–1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading–unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
Emotionally Tough, Sexting Rough: Relationship Between Callous Unemotional Traits and Aggravated Sexting in 11 Countries
(Colegio Oficial de Psicologos de Asturias, 2025) Morelli, Mara; Rosati, Fau; Cattelino, Elena; Urbini, Flavio; Baiocco, Roberto; Bianchi, Dora; Chirumbolo, Antonio; Toplu-Demirtaş, Ezgi
Background: Sexting is now widely acknowledged as a common sexual behavior among adolescents and young adults. However, the occurrence of abusive interactions, such as non-consensual sexting, warrants attention. Prevalence rates of non-consensual sexting vary between countries, influenced by gender and age. The present study examined the relationship between three facets of callous-unemotional (CU) traits (i.e., callousness, uncaring, and unemotional) and the sharing of non-consensual sexts across different relationship contexts (i.e., acquaintances, strangers, or partners). Method: Data were drawn from a cross-countries project encompassing 11 countries: Belgium, China, Czech Republic, Ireland, Italy, Malaysia, Poland, Russia, Turkey, Uganda, and the USA. The sample comprised 6093 young adults (3682 girls; 2401 boys), aged 13 to 30 (M = 20.35; SD = 3.63). Results: Results from a logistic mixed-model indicate that CU traits predict non-consensual sexting, with high callousness and uncaring, and low unemotional traits associated with non-consensual sexting involving partners and strangers. Younger individuals and women were more likely to engage in all forms of non-consensual sexting compared to older individuals and men. Conclusions: It is important to promote sexual education programs to increase emotional self-awareness and challenge gender stereotypes in order to reduce adverse outcomes associated with sexting.
Citation - WoS: 1
Citation - Scopus: 1
Estimated Probabilities of Positive, Vs. Negative, Events Show Separable Correlations With Covid-19 Preventive Behaviours
(Elsevier, 2022) Aksu, Ayça; Booth, Robert W.; Yavuz, Burak Baran; Peker, Müjde
Research has associated optimism with better health-protective behaviours, but few studies have measured optimism or pessimism directly, by asking participants to estimate probabilities of events. We used these probability estimates to examine how optimism and/or pessimism relate to protecting oneself from COVID-19. When COVID-19 first reached Turkey, we asked a snowball sample of 494 Istanbul adults how much they engaged in various COVID-protective behaviours. They also estimated the probabilities of their catching COVID-19, and of other positive and negative events happening to them. Estimated probability of general positive events (optimism) correlated positively with officially-recommended helpful behaviours (e.g. wearing masks), but not with less-helpful behaviours (e.g. sharing ‘alternative’ COVID-related information online). Estimated probabilities of general negative events (pessimism), or of catching COVID, did not correlate significantly with helpful COVID-related behaviours; but they did correlate with psychopathological symptoms, as did less-helpful COVID-related behaviours. This shows important nuances can be revealed by measuring optimism and pessimism, as separate variables, using probability estimates.
Examining Factors Influencing Turkish Jewish Attitudes Towards the Armenian Genocide
(Wiley, 2024) Kaymak, Özgür; Nefes, Türkay Salim; Gürpınar, Doğan
The most prominent issue influencing Turkish-Armenian relations is the international recognition of the Armenian genocide. However, there is a notable absence of empirical analyses regarding the perceptions of the genocide among the Turkish population. This study aims to fill this scholarly gap by exploring, for the first time, the perspectives of Turkish Jews. It analyses evidence collected from interviews conducted with 14 Turkish Jews, utilising Stanley Cohen's (2001) theoretical framework, which aids in delineating significant factors by a categorisation of types of acceptance and denial. The findings highlight a diversity of responses linked to political attitudes, which can be broadly categorised into Kayades and Avlaremoz mindsets. They also show that Turkish Jews' views on the Holocaust influence how they perceive the Armenian genocide. Additionally, the results indicate that Cohen's approach is useful in explaining non-denying responses. In conclusion, the study argues that Turkish Jews' perspectives appear to be strongly related to their stance towards the Turkish state and the Holocaust.
Citation - WoS: 4
Citation - Scopus: 5
Feeling Guilt and Shame Upon Psychological Dating Violence Victimization in College Women : the Further Role of Sexism
(SAGE Publications, 2022) Fincham, D. Frank; Demirtaş, Toplu Ezgi; Öztemür, Gizem; Oflaz, Çiğdem
Dating violence is manifested in different forms between romantic partners. Psychological violence, the most common form of dating violence, is more likely to affect women, eliciting feelings such as shame and guilt. The robust relationship of sexism to psychological dating violence victimization (PDVV) is well-documented but whether PDVV serves as a mechanism linking sexism to guilt and shame remains unexplored. This study, therefore, investigated the potential mediating role of PDVV in the association between sexist attitudes and feelings of guilt and shame. Dating college women (N = 219) from Turkey, an honor culture in which one’s self-worth lies on one’s evaluation as well as the assessment of what others think, participated in the study. High rates of PDVV were found in this culture, and structural equation modeling revealed that PDVV mediated the relationship between sexism and feelings of guilt and shame. These findings are discussed in terms of their implications for future research and how sexist attitudes might be challenged to reduce the adverse emotional effects experienced by women who are victims of psychological dating violence.
Citation - WoS: 20
Citation - Scopus: 17
Feelings of Burden Among Family Caregivers of People With Spinal Cord Injury in Turkey
(Springer Nature, 2017) Yavuz, H. Melis; Selçuk, Bilge; Seçinti, Ekin
Study design: The study was designed as a cross-sectional survey. Objectives: The purpose of the study was to examine the level of feelings of burden in family caregivers of people with spinal cord injury (SCI) in Turkey, and to explore its predictors. Setting: Turkey. Methods: One hundred family caregivers of people with SCI completed measures of burden of caregiving, depression, social support and physical health. The SCI participants completed a measure of functional independence. Multivariate statistics and structural equation modeling (SEM) were conducted to identify significant predictors of caregiver burden. Results: Caregiver burden was significantly related to caregivers’ feelings of depression. SEM analysis showed that social support from family and from friends predicted caregiver burden via depression. Caregivers’ age, sex, educational level, physical health and household income did not significantly predict their feelings of depression or burden. Conclusions: Our findings revealed that support received from both families and friends is an important source for alleviating the depressive feelings of caregivers and, in return, their burden in the caregiving. In Turkey, high support from family members is expected and is important for psychological well-being, yet the current study showed that the support received from friends also has unique contribution to the well-being of the caregivers of persons with SCI. Overall, our findings highlight the importance of supportive relationships between family as well as friends for the caregivers who may have to provide lifetime care for their family member with special needs.
Citation - WoS: 5
Citation - Scopus: 5
Health Outcomes Among Patients Diagnosed With Schizophrenia in the Us Veterans Health Administration Population Who Transitioned From Once-Monthly To Once-Every Paliperidone Palmitate: an Observational Retrospective Analysis
(Springer, 2019) Khouyr, Antoine El; Wang, Li; Joshi, Kruti; Patel, Charmi; Başer, Onur; Huang, Ahong
There is limited literature on treatment patterns, healthcare resource utilization (HRU), and costs among patients who transition from once-monthly paliperidone palmitate (PP1M) to once-every-3-month paliperidone palmitate (PP3M) in a real-world setting. Hence, this study compared treatment patterns, HRU, and costs 12-month pre- and post-PP3M transition among Veteran’s Health Administration (VHA) patients with schizophrenia.
Citation - WoS: 6
Citation - Scopus: 7
Hematocrit Levels and Thrombotic Events in Patients With Polycythemia Vera: an Analysis of Veterans Health Administration Data
(Springer, 2019) Parasuraman, Shreekant; Robyn Scherber; Jingbo Yu; Li Wang; Dilan Paranagama; Sulena Shrestha; Başer, Onur
Patients with polycythemia vera (PV) have a high incidence of thrombotic events (TEs), contributing to a greater mortality risk than the general population. The relationship between hematocrit (HCT) levels and TE occurrence among patients with PV from the Veterans Health Administration (VHA) was evaluated to replicate findings of the CYTO-PV trial with a real-world patient population. This retrospective study used VHA medical record and claims data from the first claim with a PV diagnosis (index) until death, disenrollment, or end of study, collected between October 1, 2005, and September 30, 2012. Patients were aged ? 18 years at index, had ? 2 claims for PV (ICD-9-CM code, 238.4) ? 30 days apart during the identification period, continuous health plan enrollment from 12 months pre-index until end of study, and ? 3 HCT measurements per year during follow-up. This analysis focused on patients with no pre-index TE, and with all HCT values either < 45% or ? 45% during the follow-up period. The difference in TE risk between HCT groups was assessed using unadjusted Cox regression models based on time to first TE. Patients (N = 213) were mean (SD) age 68.9 (11.5) years, 98.6% male, and 61.5% white. TE rates for patients with HCT values < 45% versus ? 45% were 40.3% and 54.2%, respectively. Among patients with ? 1 HCT before TE, TE risk hazard ratio was 1.61 (95% CI, 1.03–2.51; P = 0.036). This analysis of the VHA population further supports effective monitoring and control of HCT levels < 45% to reduce TE risk in patients with PV.

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