PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1928

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Citation - WoS: 9
Citation - Scopus: 9
A Longitudinal Assessment of Variability in Covid-19 Vaccine Hesitancy and Psychosocial Correlates in a National United States Sample
(Elsevier Sci Ltd, 2023) Shook, Natalie J.; Oosterhoff, Benjamin; Sevi, Barış
Recent evidence suggests that COVID-19 vaccine hesitancy is not static. In order to develop effective vaccine uptake interventions, we need to understand the extent to which vaccine hesitancy fluctuates and identify factors associated with both between- and within-person differences in vaccine hesitancy. The goals of the current study were to assess the extent to which COVID-19 vaccine hesitancy varied at an individual level across time and to determine whether disgust sensitivity and germ aversion were associated with between- and within-person differences in COVID-19 vaccine hesitancy. A national sample of U.S. adults (N = 1025; 516 woman; M-age = 46.34 years, SDage = 16.56, range: 18 to 85 years; 72.6 % White) completed six weekly online surveys (March 20 - May 3, 2020). Between-person mean COVID-19 vaccine hesitancy rates were relatively stable across the six-week period (range: 38-42 %). However, there was considerable within-person variability in COVID-19 vaccine hesitancy. Approximately, 40 % of the sample changed their vaccine hesitancy at least once during the six weeks. There was a significant between-person effect for disgust sensitivity, such that greater disgust sensitivity was associated with a lower likelihood of COVID-19 vaccine hesitance. There was also a significant within-person effect for germ aversion. Participants who experienced greater germ aversion for a given week relative to their own six week average were less likely to be COVID-19 vaccine hesitant that week relative to their own six-week average. This study provides important information on rapidly changing individual variability in COVID-19 vaccine hesitancy on a weekly basis, which should be taken into consideration with any efforts to decrease vaccine hesitancy and increase vaccine uptake. Further, these findings identify-two psychological factors (disgust sensitivity and germ aversion) with malleable components that could be leveraged in developing vaccine uptake interventions.
Citation - WoS: 25
Citation - Scopus: 26
Acoustic Particle Palpation for Measuring Tissue Elasticity
(American Institute of Physics, 2015) El Ghamrawy, Ahmed; Körük, Hasan; Choi, James J; Pouliopoulos, Antonios N
We propose acoustic particle palpation—the use of sound to press a population of acoustic particles against an interface—as a method for measuring the qualitative and quantitative mechanical properties of materials. We tested the feasibility of this method by emitting ultrasound pulses across a tunnel of an elastic material filled with microbubbles. Ultrasound stimulated the microbubble cloud to move in the direction of wave propagation, press against the distal surface, and cause deformations relevant for elasticity measurements. Shear waves propagated away from the palpation site with a velocity that was used to estimate the material’s Young’s modulus.
Citation - WoS: 13
Citation - Scopus: 17
Acoustic Streaming in a Soft Tissue Microenvironment
(Elsevier, 2019) El Ghamrawy, Ahmed; Mohammed, Ali; Jones, Julian R; Körük, Hasan; Choi, James J; de Comtes, Florentina
We demonstrated that sound can push fluid through a tissue-mimicking material. Although acousticstreaming in tissue has been proposed as a mechanism for biomedical ultrasound applications, such as neuromodu-lation and enhanced drug penetration, streaming in tissue or acoustic phantoms has not been directly observed. Wedeveloped a material that mimics the porous structure of tissue and used a dye and a video camera to track fluidmovement. When applied above an acoustic intensity threshold, a continuous focused ultrasound beam (spatialpeak time average intensity: 238 W/cm2, centre frequency: 5 MHz) was found to push the dye axially, that is, in thedirection of wave propagation and in the radial direction. Dye clearance increased with ultrasound intensity andwas modelled using an adapted version of Eckart’s acoustic streaming velocity equation. No microstructuralchanges were observed in the sonicated region when assessed using scanning electron microscopy. Our study indi-cates that acoustic streaming can occur in soft porous materials and provides a mechanistic basis for future use ofstreaming for therapeutic or diagnostic purposes.
Citation - WoS: 42
Citation - Scopus: 50
Adaptive Human Force Scaling Via Admittance Control for Physical Human-Robot Interaction
(IEEE, 2021) Başdoğan, Çağatay; Aydın, Yusuf; Hamad, Yahya M.
The goal of this article is to design an admittance controller for a robot to adaptively change its contribution to a collaborative manipulation task executed with a human partner to improve the task performance. This has been achieved by adaptive scaling of human force based on her/his movement intention while paying attention to the requirements of different task phases. In our approach, movement intentions of human are estimated from measured human force and velocity of manipulated object, and converted to a quantitative value using a fuzzy logic scheme. This value is then utilized as a variable gain in an admittance controller to adaptively adjust the contribution of robot to the task without changing the admittance time constant. We demonstrate the benefits of the proposed approach by a pHRI experiment utilizing Fitts’ reaching movement task. The results of the experiment show that there is a) an optimum admittance time constant maximizing the human force amplification and b) a desirable admittance gain profile which leads to a more effective co-manipulation in terms of overall task performance.
Citation - WoS: 17
Citation - Scopus: 23
Benefit of Early Discharge Among Patients With Low-Risk Pulmonary Embolism
(2017) Wang, Li; Wells, Phil; Fermann, Gregory J; Peacock, W. Frank; Schein, Jeff; Coleman, Craig I; Crivera, Concetta; Başer, Onur
Clinical guidelines recommend early discharge of patients with low-risk pulmonary embolism (LRPE). This study measured the overall impact of early discharge of LRPE patients on clinical outcomes and costs in the Veterans Health Administration population. Adult patients with >= 1 inpatient diagnosis for pulmonary embolism (PE) (index date) between 10/2011-06/2015, continuous enrollment for >= 12 months pre-and 3 months post-index date were included. PE risk stratification was performed using the simplified Pulmonary Embolism Stratification Index. Propensity score matching (PSM) was used to compare 90-day adverse PE events (APEs) [recurrent venous thromboembolism, major bleed and death], hospital-acquired complications (HACs), healthcare utilization, and costs among short (<= 2 days) versus long length of stay (LOS). Net clinical benefit was defined as 1 minus the combined rate of APE and HAC. Among 6,746 PE patients, 95.4% were men, 22.0% were African American, and 1,918 had LRPE. Among LRPE patients, only 688 had a short LOS. After 1:1 PSM, there were no differences in APE, but short LOS had fewer HAC (1.5% vs 13.3%, 95% CI: 3.77-19.94) and bacterial pneumonias (5.9% vs 11.7%, 95% CI: 1.24-3.23), resulting in better net clinical benefit (86.9% vs 78.3%, 95% CI: 0.84-0.96). Among long LOS patients, HACs (52) exceeded APEs (14 recurrent DVT, 5 bleeds). Short LOS incurred lower inpatient ($2,164 vs $5,100, 95% CI: $646.8-$5225.0) and total costs ($9,056 vs $12,544, 95% CI: $636.6-$6337.7). LRPE patients with short LOS had better net clinical outcomes at lower costs than matched LRPE patients with long LOS.
Citation - WoS: 1
Citation - Scopus: 1
Body Appreciation Matters: The Associations Between Self-Compassion, Body Appreciation, and Disordered Eating Behaviors Among Heterosexual and LGBI+ Emerging Adults in Türkiye
(SAGE Publications Inc., 2025) Deveci, A.N.; Toplu-Demirtaş, E; Bulgan, G.
Objectives: Self-compassion has been effective in the prevention and treatment of disordered eating behaviors and body image issues, which are significant public health concerns with potential psychosocial and physical consequences. Furthermore, there remains a substantial gap in the existing body of research, particularly in the context of heterosexual, lesbian, gay, and bisexual plus (LGBi+) emerging adults in Türkiye. Therefore, this study aims to explore the mediating role of body appreciation in the relationship between self-compassion and disordered eating behaviors and the moderating role of sexual orientation (heterosexual and LGBi+) in the mediation among emerging adults. Methods: A diverse sample of participants comprising heterosexual (n = 242) and LGBi+ (n = 204) emerging adults (Mage = 22.18; SDage = 3.07; min = 18; max = 30) completed self-report measures of the Self-Compassion Scale, Body Appreciation Scale-2, and Eating Attitude Test-26. Results: The results of moderated meditation revealed that body appreciation mediated the relationship between self-compassion and disordered eating behaviors among both heterosexual and LGBi+ individuals. Conclusions: The findings may inform support strategies and interventions to reduce eating disorder risk and promote mental health and well-being in both heterosexual and LGBi+ populations by emphasizing self-compassion and body appreciation. © The Author(s) 2025
Citation - WoS: 1
Citation - Scopus: 3
Brief Time Course of Trait Anxiety-Related Attentional Bias To Fearconditioned Stimuli: Evidence From the Dual-Rsvp Task
(Elsevier, 2016) Booth, Robert William
Background and objectives Attentional bias to threat is a much-studied feature of anxiety; it is typically assessed using response time (RT) tasks such as the dot probe. Findings regarding the time course of attentional bias have been inconsistent, possibly because RT tasks are sensitive to processes downstream of attention. Methods Attentional bias was assessed using an accuracy-based task in which participants detected a single digit in two simultaneous rapid serial visual presentation (RSVP) streams of letters. Before the target, two coloured shapes were presented simultaneously, one in each RSVP stream; one shape had previously been associated with threat through Pavlovian fear conditioning. Attentional bias was indicated wherever participants identified targets in the threat’s RSVP stream more accurately than targets in the other RSVP stream. Results In 87 unselected undergraduates, trait anxiety only predicted attentional bias when the target was presented immediately following the shapes, i.e. 160 ms later; by 320 ms the bias had disappeared. This suggests attentional bias in anxiety can be extremely brief and transitory. Limitations This initial study utilised an analogue sample, and was unable to physiologically verify the efficacy of the conditioning. The next steps will be to verify these results in a sample of diagnosed anxious patients, and to use alternative threat stimuli. Conclusions The results of studies using response time to assess the time course of attentional bias may partially reflect later processes such as decision making and response preparation. This may limit the efficacy of therapies aiming to retrain attentional biases using response time tasks.
Citation - WoS: 7
Citation - Scopus: 7
But the Poor Needed It More: Children's Judgments on Procedural Justice To Allocate Resources Between Two Candidates Equal in Merit, Different in Need
(Elsevier Science Inc, 2023) Sıvış, Özce; Acar, Melike
The current study investigated children's judgments on procedural justice and its outcomes when the candidates were equal in merit but different in need. A total of 88 children (41 girls and 47 boys) aged 7 to 11 years were individually interviewed (Mage = 8 years 9 months, SD = 14.065 months). Results showed that, regardless of age, children tended to give educational resources to the resource-poor candidates. However, children's welfare considera-tion of the resource-poor candidates increased with age. Children also made differentiated judgments based on the resource type and treated educational materials as more necessary than educa-tional experiences. Children's age and socioeconomic status (SES) were associated with this differentiation. Younger and high-SES children were more likely to view the outcome of procedural jus-tice (i.e., drawing a stick) for allocating an educational experience (i.e., summer camp) as fair when the result favored the resource -rich candidate. Overall, findings revealed that children do not use a unitary form of fairness in the procedural justice context. The shift from strict equality to welfare concerns continues to develop over middle childhood. (c) 2023 Elsevier Inc. All rights reserved.
Citation - WoS: 41
Citation - Scopus: 39
Clinical and Economic Burden Associated With Cardiovascular Events Among Patients With Hyperlipidemia: a Retrospective Cohort Study
(2016) Wang, Li; Quek, Ruben G. W; Fox, Kathleen M; Gandra, Shravanthi R; Li, Lu; Başer, Onur
Background: Annual direct costs for cardiovascular (CV) diseases in the United States are approximately $195.6 billion, with many high-risk patients remaining at risk for major cardiovascular events (CVE). This study evaluated the direct clinical and economic burden associated with new CVE up to 3 years post-event among patients with hyperlipidemia. Methods: Hyperlipidemic patients with a primary inpatient claim for new CVE (myocardial infarction, unstable angina, ischemic stroke, transient ischemic attack, coronary artery bypass graft, percutaneous coronary intervention and heart failure) were identified using IMS LifeLink PharMetrics Plus data from January 1, 2006 through June 30, 2012. Patients were stratified by CV risk into history of CVE, modified coronary heart disease risk equivalent, moderate-and low-risk cohorts. Of the eligible patients, propensity score matched 243,640 patients with or without new CVE were included to compare healthcare resource utilization and direct costs ranging from the acute (1-month) phase through 3 years post-CVE date (follow-up period). Results: Myocardial infarction was the most common CVE in all the risk cohorts. During the acute phase, among patients with new CVE, the average incremental inpatient length of stay and incremental costs ranged from 4.4-6.2 days and $25,666-$30,321, respectively. Acute-phase incremental costs accounted for 61-75 % of first-year costs, but incremental costs also remained high during years 2 and 3 post-CVE. Conclusions: Among hyperlipidemic patients with new CVE, healthcare utilization and costs incurred were significantly higher than for those without CVE during the acute phase, and remained higher up to 3 years post-event, across all risk cohorts.
Citation - WoS: 13
Citation - Scopus: 17
Consistency of Adults’ Earliest Memories Across Two Years
(Taylor & Francis, 2019) Gülgöz, Sami; Demiray, Burcu; Ece, Berivan
The consistency of earliest memories in content, dating, and memory qualities was investigated. A total of 84 (27 males; Mage = 24.93, SD = 1.36) adults reported earliest memories, estimated ages, and rated their recollections on memory qualities with a two-year time lag. At Time 2, their original reports at Time 1 were presented and they were asked to report whether the earliest memories they recalled at Time 2 were the same. Fifty-six per cent of the participants reported the same earliest memories and those remembering the same events had earlier memories than those remembering different ones. Although no significant differences were observed in estimated ages on the basis of mean ages, a predating bias of later memories and a tendency to postdate earlier memories were observed on the basis of a 48-month cut-off point. Thus, how the data is analysed is critical in detecting dating biases or errors affecting conclusions and interpretations about the dating consistency of earliest memories. Finally, memory qualities of earliest memories displayed a high level of consistency with a two-year time lag regardless of remembering the same versus different event.
Citation - WoS: 22
Citation - Scopus: 23
Culturally Shared and Unique Meanings and Expressions of Maternal Control Across Four Cultures
(American Psychological Association, 2021) Selçuk, Bilge; Cheah, Charissa S L; Şen, Hilal H.; Park, Seong-Yeon; Vu, Kathy T T; Cho, Hyun Su; Yavuz, H Melis
Maternal control is a major dimension of parenting and has different meanings, practices, and potential consequences across cultures. The present study aimed to identify and compare mothers' conceptualizations of parenting control across four cultures to reveal a more nuanced understanding regarding the meaning and practices of control: European American, Chinese immigrant, Korean immigrant, and Turkish. Using a semistructured open-ended interview, 100 European American, 102 U.S. Chinese immigrant, 103 U.S. Korean immigrant, and 109 Turkish mothers of preschool-aged children reported the ratings of importance, specific reasons, and strategies for exerting control over their children in daily life. Results revealed both shared and unique conceptualizations of maternal control across four cultures. Specifically, all mothers reported that it is important to express maternal control over their children in order to set behavioral norms/standards, maintain child safety, support social relations and respect for others, provide guidance, and guide moral development. Moreover, mothers discussed utilizing nonphysical punishment, setting and maintaining rules, reasoning/negotiating, consistency, physical punishment and verbal control, showing parents' serious/stern attitude, correction, and psychological control forms of control. However, the levels at which mothers emphasize the different reasons and strategies varied across cultures, reflecting culturally emphasized values. The findings of the present study further enrich our understanding of the complexities of maternal control across cultures. (PsycInfo Database Record
Citation - WoS: 14
Citation - Scopus: 15
Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force
(Elsevier, 2020) Körük, Hasan; Bezer, James H.; J Rowlands, Christopher; Choi, James J.
Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25–100 µm, Young's modulus: 2–8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6–1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading–unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
Citation - WoS: 13
Citation - Scopus: 15
Emotional Dependency and Dysfunctional Relationship Beliefs as Predictors of Married Turkish Individuals’ Relationship Satisfaction
(Cambridge University Press, 2016) Çetinkaya Yıldız, Evrim; Kemer, Gülşah; Bulgan, Gökçe
In this study, we examined married individuals’ relationship satisfaction in relation to their emotional dependency and dysfunctional relationship beliefs. Our participants consisted of 203 female and 181 male, a total of 384 married individuals from urban cities of Turkey. Controlling the effects of gender and length of marriage, we performed a hierarchical regression analysis. Results revealed that married Turkish individuals’ relationship satisfaction was significantly explained by their emotional dependency (sr2 = .300, p < .001), and perceptions of interpersonal rejection (sr2 = .075, p < .001) and unrealistic relationship expectations (sr2 = .028, p < .001). However, interpersonal misperception did not make a significant contribution to the participants’ relationship satisfaction (p > .05). When compared to perceptions of interpersonal rejection and unrealistic relationship expectations, emotional dependency had the largest role in explaining participants’ satisfaction with their marriages. We discuss the results in light of current literature as well as cultural relevance. We also provide implications for future research and mental health practices.
Citation - WoS: 1
Citation - Scopus: 1
Estimated Probabilities of Positive, Vs. Negative, Events Show Separable Correlations With Covid-19 Preventive Behaviours
(Elsevier, 2022) Aksu, Ayça; Booth, Robert W.; Yavuz, Burak Baran; Peker, Müjde
Research has associated optimism with better health-protective behaviours, but few studies have measured optimism or pessimism directly, by asking participants to estimate probabilities of events. We used these probability estimates to examine how optimism and/or pessimism relate to protecting oneself from COVID-19. When COVID-19 first reached Turkey, we asked a snowball sample of 494 Istanbul adults how much they engaged in various COVID-protective behaviours. They also estimated the probabilities of their catching COVID-19, and of other positive and negative events happening to them. Estimated probability of general positive events (optimism) correlated positively with officially-recommended helpful behaviours (e.g. wearing masks), but not with less-helpful behaviours (e.g. sharing ‘alternative’ COVID-related information online). Estimated probabilities of general negative events (pessimism), or of catching COVID, did not correlate significantly with helpful COVID-related behaviours; but they did correlate with psychopathological symptoms, as did less-helpful COVID-related behaviours. This shows important nuances can be revealed by measuring optimism and pessimism, as separate variables, using probability estimates.
Citation - WoS: 5
Citation - Scopus: 4
Favoring Inequalities and Mind-Reading: Social Dominance Orientation Relates To Poor Mentalizing
(Sage Publications Inc, 2023) Ekerim-Akbulut, Müge; Selçuk, Bilge
Although studies have so far investigated social dominance orientation (SDO) in relation to its association with prejudice and discrimination toward outgroups, it is not known whether SDO's link with poor intergroup relations might be underlined by specific socio-cognitive factors such as reduced mind-reading motivation (MRM) and poor mind-reading performance. The present study tested whether endorsement of SDO is associated with decreased MRM and mind-reading accuracy toward both ingroup and outgroup targets. We randomly assigned one hundred and 20 Turkish university students (M- age = 22.02) into two target groups for mind-reading, Turkish ingroup (N = 60) and Syrian outgroup (N = 60), and asked them to infer minds of either ingroup or outgroup members depending on their target group. Participants also reported their level of MRM and SDO through questionnaires. When the target was a Turkish ingroup member, SDO negatively and directly predicted mind-reading, when the target was an outgroup member, however, higher SDO indirectly predicted lower mind-reading through reduced MRM. These results pointed that favoring intergroup hierarchies relates to poor understanding of others' mental states although the mechanism of the relation changes depending on the group membership of the target.
Citation - WoS: 20
Citation - Scopus: 18
Feelings of Burden Among Family Caregivers of People With Spinal Cord Injury in Turkey
(Springer Nature, 2017) Yavuz, H. Melis; Selçuk, Bilge; Seçinti, Ekin
Study design: The study was designed as a cross-sectional survey. Objectives: The purpose of the study was to examine the level of feelings of burden in family caregivers of people with spinal cord injury (SCI) in Turkey, and to explore its predictors. Setting: Turkey. Methods: One hundred family caregivers of people with SCI completed measures of burden of caregiving, depression, social support and physical health. The SCI participants completed a measure of functional independence. Multivariate statistics and structural equation modeling (SEM) were conducted to identify significant predictors of caregiver burden. Results: Caregiver burden was significantly related to caregivers’ feelings of depression. SEM analysis showed that social support from family and from friends predicted caregiver burden via depression. Caregivers’ age, sex, educational level, physical health and household income did not significantly predict their feelings of depression or burden. Conclusions: Our findings revealed that support received from both families and friends is an important source for alleviating the depressive feelings of caregivers and, in return, their burden in the caregiving. In Turkey, high support from family members is expected and is important for psychological well-being, yet the current study showed that the support received from friends also has unique contribution to the well-being of the caregivers of persons with SCI. Overall, our findings highlight the importance of supportive relationships between family as well as friends for the caregivers who may have to provide lifetime care for their family member with special needs.
Citation - WoS: 7
Citation - Scopus: 8
Hematocrit Levels and Thrombotic Events in Patients With Polycythemia Vera: an Analysis of Veterans Health Administration Data
(Springer, 2019) Parasuraman, Shreekant; Robyn Scherber; Jingbo Yu; Li Wang; Dilan Paranagama; Sulena Shrestha; Başer, Onur
Patients with polycythemia vera (PV) have a high incidence of thrombotic events (TEs), contributing to a greater mortality risk than the general population. The relationship between hematocrit (HCT) levels and TE occurrence among patients with PV from the Veterans Health Administration (VHA) was evaluated to replicate findings of the CYTO-PV trial with a real-world patient population. This retrospective study used VHA medical record and claims data from the first claim with a PV diagnosis (index) until death, disenrollment, or end of study, collected between October 1, 2005, and September 30, 2012. Patients were aged ? 18 years at index, had ? 2 claims for PV (ICD-9-CM code, 238.4) ? 30 days apart during the identification period, continuous health plan enrollment from 12 months pre-index until end of study, and ? 3 HCT measurements per year during follow-up. This analysis focused on patients with no pre-index TE, and with all HCT values either < 45% or ? 45% during the follow-up period. The difference in TE risk between HCT groups was assessed using unadjusted Cox regression models based on time to first TE. Patients (N = 213) were mean (SD) age 68.9 (11.5) years, 98.6% male, and 61.5% white. TE rates for patients with HCT values < 45% versus ? 45% were 40.3% and 54.2%, respectively. Among patients with ? 1 HCT before TE, TE risk hazard ratio was 1.61 (95% CI, 1.03–2.51; P = 0.036). This analysis of the VHA population further supports effective monitoring and control of HCT levels < 45% to reduce TE risk in patients with PV.
Citation - WoS: 25
Citation - Scopus: 25
Impact of Switching From an Initial Tumor Necrosis Factor Inhibitor on Health Care Resource Utilization and Costs Among Patients With Rheumatoid Arthritis
(2015) Roy, Sanjoy; Ganguli, Arijit; Xie, Lin; Başer, Onur; Cifaldi, Mary
Purpose: Despite improved clinical outcomes for the majority of patients, nearly 30% of patients with rheumatoid arthritis (RA) who initiate tumor necrosis factor antagonist (anti-TNF) biologic agents fail to respond to their first-line anti-TNF and switch to another anti-TNF or a non-TNF biologic. How this change affects health care costs and resource utilization is unknown. We therefore compared RA patients taking first-line anti-TNFs who switched to a second anti-TNF versus those patients who switched to an alternate biologic. Methods: Health care claims data were obtained from a large US database for eligible adults with confirmed RA diagnoses who initiated anti-TNF treatment and switched to another biologic. Health care costs and utilization during the first 12 months' postswitch were compared. Generalized linear models were used to adjust for differences in demographic and clinical characteristics before switching. Findings: Patients who switched to a second anti-TNF rather than a non-TNF biologic were generally younger (53.0 vs. 55.3 years; P < 0.0001) and less likely to be female (79.7% vs. 82.7%; P = 0.0490). Of the 3497 eligible patients who switched from first-line anti-TNFs, 2563 (73.3%) switched to another anti-TNF and 934 (26.7%) switched to a non-TNF. Adalimumab was the most frequently prescribed (43.4%) second-line anti-TNF, and abatacept was the most common non anti-TNF (71.4%). Patients who switched to a second anti-TNF remained on their first medication for a significantly shorter period (342.5 vs 420.6 days; P < 0.0001) and had lower comorbidity indices and higher disease severity at baseline than those who switched to a non anti-TNF. After adjusting for baseline differences, patients who switched to second anti-TNFs versus a non-TNF incurred lower RA-related costs ($20,938.9 vs $22,645.2; P = 0.0010) and total health care costs ($34,894.6 vs $38,437.2; P = 0.0010) 1 year postswitch. These differences were driven by increased physician office visit costs among the non-TNF group. Implications: Among the anti-TNF initiators who switched therapy, more patients switched to a second anti-TNF than to a non-TNF. Switching to a second anti-TNF treatment was associated with lower all-cause and RA-related health care costs and resource utilization than switching to a non-TNF. Because switching therapy may be unavoidable, finding a treatment algorithm mitigating this increase to any extent should be considered. These data are limited by their retrospective design. Additional confounding variables that could not be controlled for may affect results. (C) 2015 The Authors. Published by Elsevier HS journals, Inc.
Longitudinal Relations Between Early Prosocial Behaviors Toward Parents and Later Prosocial and Aggressive Behaviors in Turkish Early Adolescents
(2025) Gulseven, Zehra; Kumru, Asiye; Carlo, Gustavo; Maiya, Sahitya; Sayil, Melike; Selcuk, Bilge
Citation - WoS: 5
Citation - Scopus: 6
Measurement Invariance of the Moral Vitalism Scale Across 28 Cultural Groups
(Public Library of Science, 2020) Bilewicz, Michal; Kuppens, Peter; Crespo, Carla; Collier-Baker, Emma; Fischer, Ronald; Pelay, Cesar; Peker, Müjde; Pina, Afroditi; Karasawa, Minoru; Hooper, Nic; Vauclair, Christin-Melanie; Friese, Malte; AminihajibashiI, Samira; Wailan Yeung, Victoria; Rudnev, Maksim; Eastwic, Paul; Luis Castellanos Guevara, Jose; Saguy, Tamar; Silfver-Kuhalampi, Mia; Gomez, Angel; Becker, Maja; Loughnan, Steve; Bastian, Brock; Swann, William; Tong, Jennifer (Yuk-Yue); Sortheix, Florencia; Guerra, Valeschka; Huang, Li-li; Shi, Junqi; Hanke, Katja; Sachkova, Marianna
Moral vitalism refers to a tendency to view good and evil as actual forces that can influence people and events. The Moral Vitalism Scale had been designed to assess moral vitalism in a brief survey form. Previous studies established the reliability and validity of the scale in US-American and Australian samples. In this study, the cross-cultural comparability of the scale was tested across 28 different cultural groups worldwide through measurement invariance tests. A series of exact invariance tests marginally supported partial metric invariance, however, an approximate invariance approach provided evidence of partial scalar invariance for a 5-item measure. The established level of measurement invariance allows for comparisons of latent means across cultures. We conclude that the brief measure of moral vitalism is invariant across 28 cultures and can be used to estimate levels of moral vitalism with the same precision across very different cultural settings.

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