Ekonomi Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1936

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Now showing 1 - 8 of 8

Citation - WoS: 3
Citation - Scopus: 3
Warfarin Discontinuation in Patientswith Unprovoked Venous Thromboembolism: a Large Us Insurance Database Analysis
(2016) Mardekian, Jack; Liu, Xianchen; Phatak, Hemant; Xie, Lin; Tan, Wilson; Başer, Onur; Ramacciotti, Eduardo
This study examined warfarin therapy discontinuation and its risk factors among patients with unprovoked venous thromboembolism (VTE) in the US clinical practice setting. Adult patients with unprovoked VTE were identified from the MarketScan claims database from January 1, 2006 to December 31, 2012. The index date was defined as the date of first VTE diagnosis. Patients were required to have no VTE diagnosis in the 6 months before index date and continuous health plan enrollment for 6 months before and 12 months after the index date. Warfarin discontinuation rates and adjusted hazard ratios (HRs) were reported. Of 21,163 eligible patients, 15,463 were diagnosed with deep vein thrombosis (DVT) only (73.1%), 5027 with pulmonary embolism (PE) only (23.7%), and 673 with DVT and PE (3.2%). The average duration of warfarin therapy was 5.2 months (SD = 3.0). During 1-year follow-up, 21.4% patients discontinued therapy within 3 months, 42.8% within 6 months, and 70.1% within 12 months. PE versus DVT [HR = 0.77, 95% confidence interval (CI) = 0.74-0.80], comorbid atrial fibrillation (HR = 0.73, 95% CI = 0.66-0.81), thrombophilia (HR = 0.62, 95% CI = 0.54-0.71), and age >40 years (41-65 years: HR = 0.86, 95% CI = 0.81-0.91; >65 years: HR = 0.82, 95% CI = 0.77-0.87) were significantly associated with reduced risk of warfarin discontinuation. Alcohol abuse/dependence (HR = 1.36, 95% CI = 1.20-1.55), cancer history (HR = 1.13, 95% CI = 1.07-1.19), bleeding (HR = 1.07, 95% CI = 1.01-1.15), and catheter ablation (HR = 1.10, 95% CI = 1.00-1.20) in the 6 months before index date were significantly associated with increased risk for warfarin discontinuation. In conclusion, nearly 1 of 4 patients with unprovoked VTE discontinued warfarin within 3 months. Three of 4 patients discontinued therapy within 1 year. Younger age and multiple clinical factors are associated with warfarin therapy discontinuation.
Citation - WoS: 3
Citation - Scopus: 4
State–business Relations, Financial Access and Firm Performance: a Causal Mediation Analysis
(Wiley, 2020) Karahasan, Burhan Can; Bilgel, Fırat
This study investigates the triangular relationship among state–business relations, financial access and economic performance in the Middle East and North Africa. We hypothesize that financial intermediation is a significant mediating factor in the relationship between state–business relations and firm performance. Employing a causal mediation analysis, results show that inefficient ties with the state are a cause of poor firm performance. Inefficient state–business relations reduce firm performance by 2.3 to 4.4 per cent through access to finance and by 12 to 40 per cent via its direct effect. About 3 to 16 per cent of the total effect is mediated through financial access, while the remaining is the direct effect.
Citation - WoS: 5
Fuzzy Optimization for Portfolio Selection Based on Embedding Theorem in Fuzzy Normed Linear Spaces
(De Gruyter, 2014) Solatikia, Farnaz; Kılıç, Erdem; Weber, Gerhard-Wilhelm
In this paper, we propose a novel approach Embedding Theoremabout Menger probabilistic normed Spaces. The main idea behind ourapproach consists of taking advantage of interplays between Mengerprobabilistic normed spaces and normed spaces in a way to get anequivalent stochastic program. This helps avoiding pitfalls due to severe over simplification of the reality. The embedding theorem showsthat the set of all fuzzy numbers can be embedded into a Mengerprobabilistic Banach space. Inspired by this embedding theorem, wepropose a solution concept of fuzzy optimization problem which isobtained by applying the embedding function to the original fuzzyoptimization problem.
Citation - WoS: 4
Citation - Scopus: 2
The Economic Impact of Symptomatic Menopause Among Low-Socioeconomic Women in the United States
(2016) Başer, Onur; Keshishian, A; Xie, Lin; Wang, Yuexi
Background: Menopausal symptoms have a significant negative impact on patient's quality of life and increase healthcare costs among women. Methods: This retrospective analysis used data from a U.S. national database (01 January 2008-31 December 2010). Patients with a diagnosis of menopause symptoms or a prescription claim for hormone therapy were matched to control patients. Healthcare resource utilization and costs during the 6-month follow-up period were compared. Generalized linear models were used to adjust for differences in baseline and demographic characteristics between the cohorts. Results: A total of 71,076 patients were included in each cohort. Patients with menopausal symptoms were more likely to have depression and anxiety and incurred significantly higher follow-up healthcare costs ($7237 vs $6739, p < 0.001) and healthcare utilization during the 6-month follow-up period. Conclusion: Patients diagnosed with menopausal symptoms or treated with hormone therapy incurred significantly higher healthcare costs than those without menopausal symptoms or treatment.
Network Among Hta Ecosystem
(Springer Verlag, 2019) Çınaroğlu, Songül; Başer, Onur
This study intends to examine the main drivers of network relations among health technology assessment (HTA) organizations. Social network analysis was performed to determine the relations among HTA organizations and to visualize the main drivers of such collaboration. The members in HTA organizations such as International Society for Pharmacoeconomics and Outcomes Research, Health Technology Assessment international, International Network of Agencies for Health Technology Assessment, EuroScan, European Network for Health Technology Assessment, HTAsiaLink, and Health Technology Assessment Network for the Americas are said to create networks. Ten different HTA organizations were considered in the analysis, including the Ministry of Health (MoH) organizations, universities, for-profit organizations, and hospitals. The Fruchterman-Reingold algorithm was used to perform networking, and the average clustering coefficient and average path length were examined to measure collaborative performance. The network graph of the HTA ecosystem shows the highest collaborative frequency among HTA organizations, which are the members of MoH organizations, government agencies, universities, and nonprofit organizations. The average path length was 2.21, and the average clustering coefficient was 36.57, indicating an obvious clustering effect. The study results highlight that networking within the HTA ecosystem is driven by government organizations. Boosting the integration of the private sector into the system and creating data-sharing strategies are essential to foster HTA collaboration. Because HTA is shaped by local dynamics and no gold standard exists for HTA implementation, encouraging collaborative efforts is the only way to avoid redundant efforts and make health technologies available for everyone.
Citation - WoS: 2
Citation - Scopus: 3
Determinants of Turkish Female Labour Force Participation: an Analysis With Manufacturing Firm-Level Data
(Taylor & Francis, 2020) Karamollaoğlu, Nazlı; Soybilgen, Barış
Compared to other developing countries, Turkey has a very low female labour participation rate. Previous studies usually focus on the labour supply side of female employment. Unlike the previous literature, this paper investigates firm-level determinants of female employment in manufacturing firms using a unique micro data set constructed using different sources. After controlling for geographical variation, firm, and industry-specific factors, our results show that larger firms, exporter firms, firms with higher part-time worker ratio, and foreign-owned firms have higher female employment rate whereas younger firms, firms with higher labour productivity, and firms with long working hours have lower female employment rate.
Citation - WoS: 3
Citation - Scopus: 3
Efficiency Analysis of Social Performance – the Case of Turkish Super League
(Taylor & Francis, 2020) Donduran, Murat; Özaydın, Selçuk
Undoubtedly, due to its impact on both revenues and the home advantage, social performance is a key factor of success for football clubs. Growing revenues and the government’s eagerness to promote football in Turkey in recent years have created desirable conditions for Turkish clubs. However, research into the impact of social performance success has not received much attention, especially in Turkey, despite Turkey being one of the major leagues in Europe. This study aims to fill this gap in the literature. It does so by investigating social performance using a two-stage stochastic frontier analysis drawing on evidence from the Turkish Super League between the 2012/2013 and 2017/2018 seasons. Results from the first stage illustrate that social efficiency leaders change almost every season. Results from the second stage of research identify which specific factors are diminishing the social technical efficiency for clubs in the Turkish Super League. It emerges that the fundamental source of social inefficiency in Turkey is the Passolig, an identification system implemented in 2014. Furthermore, it transpires that heterogeneity among the clubs’ hometowns is also highly influential on social efficiency. However, even though attendance has managed to recover back to pre-Passolig levels, social efficiency is still lower than the pre-Passolig levels.
Citation - Scopus: 4
Economic Impact and Complications of Treated and Untreated Hepatitis C Virus Patients in Turkey
(2015) Altinbaş, Akif; Baser E; Kariburyo, F; Başer, Onur
Background: According to the Turkish Ministry of Health’s guidelines,standard double therapy, a combination of pegylated interferon-alphaand ribavirin, was the only treatment option for patients withhepatitis C virus (HCV) infection until the end of 2011. Objective: Theprimary objective was to compare risk-adjusted clinical and economicoutcomes between treated and untreated patients with HCV infection.Methods: Patients with HCV infection were identified from theTurkish National Health Insurance Database (2009–2011) using International Classification of Diseases, 10th Revision, Clinical Modification codes.The first prescription date was designated as the index date. Mortalityand hepatocellular carcinoma (HCC) rates and health care costs oftreated and untreated patients were compared using propensity scorematching. Baseline demographic and clinical factors were controlledin the models. Subgroup analysis was conducted for patient groupswith and without a cirrhosis diagnosis. Results: Out of 12,990 patientsincluded in the study, 1,583 were treated for HCV infection. Out of2,467 patients who had a cirrhosis diagnosis, 231 were treated,whereas out of 10,523 patients without cirrhosis, 1,352 patients weretreated. Treated patients were younger, less likely to be diagnosedwith comorbid conditions, and less likely to reside in Central orEastern Anatolia. After adjusting for baseline demographic andclinical factors, mortality (2.27% vs. 5.31%; P o 0.001) and HCC rates(0.69% vs. 1.96%; P o 0.001) were found to be lower for treatedpatients. Differences were more significant among patients diagnosedwith cirrhosis. Treated patients incurred higher risk-adjusted annualcosts (€6172 vs. €1680; P o 0.001), mainly because of pharmaceuticalcosts (€4918 vs. €583; P o 0.001). Conclusions: HCV infection treatment, although costly, significantly reduces mortality and HCC ratesin Turkey.

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