Ekonomi Bölümü Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.11779/1936
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Article Citation - Scopus: 24Epidemiology and Economic Burden of Serotonin Syndrome With Concomitant Use of Serotonergic Agents: a Retrospective Study Utilizing Two Large Us Claims Databases(Physicians Postgraduate Press Inc., 2017-12-28) Alley, Stephanie; Nguyen, Charles T.; McCarron, Robert M.; Wang, Zhixiao; Xie, Lin; Başer, OnurObjective: Serotonin syndrome (SS) is an adverse drug reaction occurring among patients receiving serotonergic agents (SAs), and although SAs are commonly prescribed, the epidemiology and economic burden of SS with concomitant SA use have not been comprehensively examined. The objective of this study was to investigate the prevalence, incidence, and economic burden of SS with SA use. Methods: A retrospective cohort study was conducted using Veterans Health Administration (VHA) records (identification period: October 1, 2008-September 30, 2012) and commercially insured patient records (Intercontinental Marketing Services PharMetrics Plus; identification period: January 1, 2010-December 31, 2013). Cohorts were based on drug classification and exposure: single monoamine oxidase inhibitor (MAOI), MAOIs in combination with SAs, single non-MAOI SA, and multiple non-MAOI SAs (2, 3, 4, ? 5). Participants were aged ? 18 years with continuous health plan enrollment for 12 months prior to the first SA claim. Outcomes were SS events (ICD-9-CM: 333.99), annual incidence and prevalence, related health care utilization and costs, and SS incidence relative risk. Results: Over 15 million patients were identified and categorized by SA prescription type. SS incidence in both populations decreased: 0.19%-0.07% (VHA) and 0.17%-0.09% (commercially insured). Overall SS prevalence decreased during the study period. Compared to single non-MAOI SA patients, SS incidence relative risk was highest among patients prescribed ? 5 non-MAOI SAs. Inpatient stays accounted for 4.35% (VHA) and 0.88% (commercially insured) of all SS events. Of SS-related inpatient stays, median costs were $8,765 (VHA) and $10,792 (commercially insured). Conclusions: SS incidence and prevalence and SS-related hospitalization risk among patients prescribed SAs were low in both populations. This study provides additional information regarding SS risk associated with SA use. © 2017, Physicians Postgraduate Press Inc. All rights reserved.Conference Object Examining the Prevalence and Incidence Rates Among Patients With Drug Dependence in the Us Veteran Population(2016) Pandya, S; Du, H; Wang, L; Başer, Onur...Conference Object Comparison of All-Cause Mortality Rate and Economic Burden Between Newly Diagnosed Alzheimer’s Disease Patients Who Received Anti-Dementia Treatment Versus Not: a Longitudinal Retrospective Study(2016) Black, CM; Hu, X; Khandker RK; Ambegaonkar, BM; Kariburyo, M. Furaha; Xie, L; Başer, Onur; Yuce, H....Conference Object Examining the Mortality and Readmission Rates of Patients Diagnosed With Stroke in the Us Medicare Population(2016) Bashyal, R; Du, H; Li Wang; Yuce H.; Başer, Onur...Conference Object Proton Pump Inhibitor Utilization Among Patients With Hepatitis C Virus (hcv)(2016) Pesa, JA; Wang, L; Yuce, H; Başer, Onur...Conference Object Comparing Health Care Resource Utilization and Costs Among Obese Patients in the Us Medicaid Population(2016) Zhang, Q; Zhao, Y; Keshishian, A; Xie, L; Yuce H.; Başer, OnurObjectives : To evaluate health care resource utilization and costs among obese patients in the U.S. Medicaid population.Conference Object Evaluating the Economic Burden and Health Care Utilization of Anemia in the Us Medicare Population(2016) Tan, H; Xie, L; Başer, Onur; Yuce, H; Wang Y....Conference Object Examination of the Economic Burden of Dyslipidemia in the Veterans Health Administration Population(2016) Keshishian, A; Tan, H; Xie, L; Başer, Onur...Conference Object Assessing Health Care Resource Utilization and Costs Among Us Veterans Diagnosed With Asthma(2016) Ogbomo, A; Tan, H; Kariburyo, F; Xie, L; Başer, Onur...Conference Object Treatment Patterns Among Newly Diagnosed Multiple Myeloma Patients in the United States Veteran Population (2010-2015)(2016) Parikh, K; Pandya, S; Abouzaid, S; Başer, Onur; Xie, L; Patel, MI....
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