Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11779/1358
Title: | Elastic deformation of soft Tissue-Mimicking materials using a single microbubble and acoustic radiation force | Authors: | Bezer, James H. Körük, Hasan J Rowlands, Christopher Choi, James J. |
Keywords: | Acoustic radiation force Bjerknes force Cavitation Drug delivery Microbubbles Ultrasound contrast agents |
Publisher: | Elsevier | Source: | Bezer, J. H., Koruk, H., Rowlands, C. J., & Choi, J. J. (January 01, 2020). Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force. Ultrasound in Medicine & Biology. | Abstract: | Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25–100 µm, Young's modulus: 2–8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6–1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading–unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects. | URI: | https://hdl.handle.net/20.500.11779/1358 https://doi.org/10.1016/j.ultrasmedbio.2020.08.012 |
ISSN: | 0301-5629 |
Appears in Collections: | Makine Mühendisliği Bölümü koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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BezerKoruk2020.pdf | Full Text - Article | 1.23 MB | Adobe PDF | View/Open |
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